Research and development for real-time dosimetry system in boron neutron capture therapy
Project/Area Number |
26860410
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Medical Physics and Radiological Technology
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Research Institution | National Cancer Center Japan |
Principal Investigator |
Nakamura Satoshi 国立研究開発法人国立がん研究センター, 中央病院, 医学物理士 (20638374)
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Research Collaborator |
ITO MASASHI
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Project Period (FY) |
2014-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | ホウ素中性子捕捉療法 / 放射線治療 / 加速器中性子捕捉療法システム / Liターゲット / 中性子 / 線量 / ホウ素中性子捕捉療法(BNCT) / 捕捉断面積 / ホウ素濃度 / 腫瘍線量 |
Outline of Final Research Achievements |
The property of an accelerator-based boron neutron capture therapy (BNCT) system was investigated to accomplish the purpose of this study, which is to develop a system to evaluate the dose to tumor in neutron capture therapy system. Using the accelerator-based BNCT system, which is installing into national cancer center hospital, Tokyo, Japan, the experiments were performed, and the relationship between the boron density and the dose to tumor could be then evaluated. Additionally, a model for the reduction of neutron flux was established since the neutron flux was reduced along the total number of neutron generation in the accelerator-based BNCT system. The reduction depended on condition of the accelerator-based BNCT system. Therefore, the signal by which the condition could be evaluated and the model was integrated in the model, and the dose to tumor could be evaluated.
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Academic Significance and Societal Importance of the Research Achievements |
本課題により行われた「腫瘍への線量を同定する」ことにより、放射線治療を現在よりも科学的に確かなものとし、今後の発展につながる。また、BNCTの不確定要素である腫瘍線量を明らかにすることは、現在行われている「リスク臓器の耐容線量を照射する」ことから脱却し、「腫瘍が治癒する線量を照射する」ことが可能とするために重要である。これにより、正常臓器の被ばくを低減でき、副作用の低減効果やがん患者の選択肢が拡大する。 また、現在の放射線治療では計画通りに照射されたことが前提で治療効果の定量を行っているが、実際に付与された線量を確かめることで従来の放射線治療よりもさらに治療効果の定量性を高めることが可能となる。
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Report
(6 results)
Research Products
(43 results)
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[Journal Article] Dependence of neutrons generated by 7Li(p, n) reaction on Li thickness under free-air condition in accelerator-based boron neutron capture therapy system employing solid-state Li target.2019
Author(s)
Nakamura S, Igaki H, Okamoto H, Wakita A, Ito M, Imamichi S, Nishioka S, Iijima K, Nakayama H, Takemori M, Kobayashi K, Abe Y, Okuma K, Takahashi K, Inaba K, Murakami N, Nakayama Y, Nishio T, Masutani M, and Itami J.
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Journal Title
Physica Medica
Volume: 58
Pages: 121-130
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Hemorrhage from ascending colon and gluteal muscle associated with sorafenib and radiotherapy: Radiation dose distribution corresponded with colonoscopy findings and computed tomography images.2019
Author(s)
Kashihara T, Murakami N, Iizumi S, Sakamoto Y, Nakamura S, Iijima K, Takahashi K, Inaba K, Okuma K, Igaki H, Nakayama Y, Okusaka T, Uno T, and Itami J.
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Journal Title
Practical Radiation Oncology
Volume: In-press
Issue: 4
Pages: 214-219
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Monte Carlo modeling of a 60Co MRI-guided radiotherapy system on Geant4 and experimental verification of dose calculation under a magnetic field of 0.35 T.2019
Author(s)
Okamoto H, Nishioka S, Iijima K, Nakamura S, Sakasai T, Miura Y, Takemori M, Nakayama H, Morishita Y, Shimizu M, Abe Y, Igaki H, Nakayama Y, and Itami J.
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Journal Title
Journal of Radiation Research
Volume: 60(1)
Issue: 1
Pages: 116-123
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Efforts toward Patient Safety: Development of System and Education of Non-Technical Skill2018
Author(s)
Okamoto H, Nakamura S, Nishioka S, Iijima K, Takemori M, Nakayama H, Aikawa A, Shibata Y, Kato T, Abe Y, Igaki H, Nakayama Y, and Itami J.
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Journal Title
Japanese Journal of Medical Physics (Igakubutsuri)
Volume: 38
Issue: 2
Pages: 62-67
DOI
ISSN
1345-5354, 2186-9634
Year and Date
2018-10-31
Related Report
Peer Reviewed / Open Access
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[Journal Article] Importance of the site of positive surgical margin in salvage external beam radiation therapy for biochemical recurrence of prostate cancer after radical prostatectomy.2018
Author(s)
Kashihara T, Nakamura S, Wakita A, Okamoto H, Inaba K, Umezawa R, Shima S, Tsuchida K, Kobayashi K, Takahashi K, Murakami N, Ito Y, Fujimoto H, Uno T, and Itami J.
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Journal Title
Cancer Medicine
Volume: 7(5)
Issue: 5
Pages: 1273-1730
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Image-guided interstitial high-dose-rate brachytherapy for locally recurrent uterine cervical cancer: A single-institution study.2018
Author(s)
Umezawa R, Murakami N, Nakamura S, Wakita A, Okamoto H, TSuchida K, Kashihara T, Kobayashi K, Harada K, Takahashi K, Inaba K, Ito Y, Igaki H, Masui K, Yoshida K, Jingu K, Tselis N, and Itami J.
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Journal Title
Brachytherapy
Volume: 17(2)
Issue: 2
Pages: 368-376
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Long-term Results of External Beam Radiotherapy for Prostate Cancer with Prostate-specific Antigen of More Than 50 ng/ml and without Evidence of Lymph Node or Distant Metastasis.2018
Author(s)
Umezawa R, Inaba K, Nakamura S, Wakita A, Okamoto H, Shima S, Tsuchida K, Kashihara T, Kobayashi K, Harada K, Takahashi K, Murakami N, Ito Y, Igaki H, Jingu K, and Itami J.
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Journal Title
Anticancer Research
Volume: 38(4)
Pages: 2303-2309
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Establishment of postal audit system in intensity-modulated radiotherapy by radiophotoluminescent glass dosimeters and a radiochromic film2018
Author(s)
Hiroyuki Okamoto,Toshiyuki Minemura, Mitsuhiro Nakamura, Hideyuki Mizuno, Naoki Tohyama, Teiji Nishio, Akihisa Wakita, Satoshi Nakamura, Shie Nishioka, Kotaro Iijima, Daisuke Fujiyama, Jun Itami, Yasumasa Nishimura
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Journal Title
Physica Medica
Volume: 48
Pages: 119-126
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Evaluation of radioactivity in the bodies of mice induced by neutron exposure from an epi-thermal neutron source of an accelerator-based boron neutron capture therapy system2017
Author(s)
Nakamura S, Imamichi S, Masumoto K, Ito M, Wakita A, Okamoto H, Nishioka S, Iijima K, Kobayashi K, Abe Y, Igaki H, Kurita K, Nishio T, Masutani M, Itami J.
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Journal Title
Proceedings of the Japan Academy, Series B
Volume: 93
Issue: 10
Pages: 821-831
DOI
NAID
ISSN
0386-2208, 1349-2896
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A management method for the statistical results of patient-specific quality assurance for intensity-modulated radiation therapy2017
Author(s)
Nakamura S, Okamoto H, Wakita A, Umezawa R, Takahashi K, Inaba K, Murakami N, Kato T, Igaki H, Ito Y, Abe Y, and Itami J
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Journal Title
Journal of Radiation Research
Volume: 印刷中
Issue: 4
Pages: 572-578
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] After low and high dose-rate interstitial brachytherapy followed by IMRT radiotherapy for intermediate and high risk prostate cancer.2016
Author(s)
Nakamura S, Murakami N, Inaba K, Wakita A, Kobayashi K, Takahashi K, Okamoto H, Umezawa R, Morota M, Sumi M, Igaki H, Ito Y, Itami J.
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Journal Title
BMC Cancer
Volume: 16
Issue: 1
Pages: 296-296
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] In vivo spatial correlation between (18)F-BPA and (18)F-FDG uptakes in head and neck cancer.2016
Author(s)
Kobayashi K, Kurihara H, Watanabe Y, Murakami N, Inaba K, Nakamura S, Wakita A, Okamoto H, Umezawa R, Takahashi K, Igaki H, Ito Y, Yoshimoto S, Shigematsu N, Itami J.
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Journal Title
Appl Radiat Isot.
Volume: 115
Pages: 138-146
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] The role of interstitial brachytherapy in the management of primary radiation therapy for uterine cervical cancer.2016
Author(s)
Murakami N, Kobayashi K, Kato T, Nakamura S, Wakita A, Okamoto H, Shima S, Tsuchida K, Kashihara T, Harada K, Takahashi K, Umezawa R, Inaba K, Ito Y, Igaki H, Itami J.
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Journal Title
J Contemp Brachytherapy.
Volume: 8
Pages: 391-398
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Dosimetric impact of an air passage on intraluminal brachytherapy for bronchus cancer2016
Author(s)
Okamoto H, Wakita A, Nakamura S, Nishioka S, Aikawa A, Kato T, Abe Y, Kobayashi K, Inaba K, Murakami N, and Itami J
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Journal Title
Journal of Radiation Research
Volume: 57 (6)
Issue: 6
Pages: 637-645
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Neutron control method for an accelerator-based BNCT system with a solid-state Li target.2018
Author(s)
Nakamura S, Igaki H, Ito M, Iijima K, Nishioka S, Takahashi K, Inaba K, Okuma K, Murakami N, Abe Y, Nakayama Y, Okamoto H, Itami J.
Organizer
18th International Congress on Neutron Capture Therapy.
Related Report
Int'l Joint Research
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[Presentation] Impact of the heterogeneity-corrected dose calculation on dose-volume parameter for APBI using SAVI2018
Author(s)
Iijima K, Okamoto H, Takahashi K, Aikawa A, Nakamura S, Nishioka S, Takemori M, Nakayama H, Sibata Y, Inaba K, Murakami N, Abe Y, Kunieda E and Itami J.
Organizer
The 31st Annual Meeting of JASTRO.
Related Report
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[Presentation] Time course changes in 18F-BPA uptake dynamics by PET scan2016
Author(s)
Igaki H, Kurihara H, Nakamura S, Wakita A, Tsuchida K, Kashihara T, Kobayashi K, Harada K, Takahashi K, Inaba K, Umezawa R, Murakami N, Ito Y, Okamoto H, and Itami J
Organizer
17th International Congress on Neutron Capture Therapy
Place of Presentation
ミズーリ(米国)
Year and Date
2016-10-02
Related Report
Int'l Joint Research
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[Presentation] Feasibility study of dose evaluation from activation of gold marker in prostate cancer treatment2016
Author(s)
Nakamura S, Suzuki Y, Okamoto H, Wakita A, Nishioka S, Iijima K, Miura Y, Ito M, Kato T, Abe Y, and Itami J
Organizer
112th Japan Society of Medical Physics
Place of Presentation
沖縄コンベンションセンター(沖縄県・宜野湾市)
Year and Date
2016-09-08
Related Report
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