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Contribution to external validity of randomized controlled trials by comparing between a mega-trial and observational studies.

Research Project

Project/Area Number 26860416
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Epidemiology and preventive medicine
Research InstitutionKyoto University

Principal Investigator

Ogawa Yusuke  京都大学, 医学(系)研究科(研究院), 助教 (50535573)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords臨床疫学 / 抗うつ薬 / 抗うつ剤 / 系統的レビュー / メタアナリシス / 観察研究 / ランダム化比較試験
Outline of Final Research Achievements

The objective of this study was to examine whether the results of effectiveness randomized controlled trials (RCTs) have external validity by comparing the results of the mega-trial which examines the optimum treatment strategy for unipolar major depressive episodes and previous observational studies of antidepressants for treatment of depression. We conducted systematic review of observational studies that reported manic switch in patients with depression treated with antidepressants. Similar results were observed between this mega-trial and observational studies. It was suggested that RCT designed to raise external validity could preserve generalizability.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Replication and contradiction of highly cited research papers in psychiatry: 10-year follow-up.2015

    • Author(s)
      Tajika A, Ogawa Y, Takeshima N, Hayasaka Y, Furukawa TA.
    • Journal Title

      Br J Psychiatry.

      Volume: 207 Issue: 4 Pages: 357-62

    • DOI

      10.1192/bjp.bp.113.143701

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mood stabilizers and antipsychotics for acute mania: a systematic review and meta-analysis of combination/augmentation therapy versus monotherapy.2014

    • Author(s)
      Ogawa Y, Tajika A, Takeshima N, Hayasaka Y, Furukawa TA.
    • Journal Title

      CNS Drugs

      Volume: 28 Issue: 11 Pages: 989-1003

    • DOI

      10.1007/s40263-014-0197-8

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] より良い診療を行うためのエビデンスの利用の仕方2015

    • Author(s)
      小川雄右
    • Organizer
      第29回日本医学会総会2015関西
    • Place of Presentation
      京都
    • Year and Date
      2015-04-11
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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