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Long term clinical consequences of intrauterine methylmercury exposure

Research Project

Project/Area Number 26860417
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Epidemiology and preventive medicine
Research InstitutionOkayama University

Principal Investigator

Yorifuji Takashi  岡山大学, 環境生命科学研究科, 准教授 (00452566)

Co-Investigator(Renkei-kenkyūsha) SANADA Satoshi (KADO Yoko)  広島文化学園, 子ども学科, 教授 (60098126)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsメチル水銀 / 食中毒 / 健康影響 / 神経認知行動学的検査 / 神経学的身体所見 / 日常生活動作 / 疫学 / 環境保健 / 水俣病 / 神経認知機能 / ADL評価 / 認知機能
Outline of Final Research Achievements

Severe methylmercury poisoning occurred in Minamata and neighboring communities in Japan during the 1950s and 1960s. A considerable number of children were born with conditions resembling cerebral palsy, later known as congenital Minamata disease. Although surviving patients are now in their 50s or 60s, few assessments of functional capacities in daily living have been performed. Moreover, possible impacts of methylmercury exposure in utero among residents, which is likely lower levels than in congenital Minamata disease patients, are rarely explored. The present study indicates that the Activities of Daily Living status of congenital Minamata disease patients, now in their 50s or 60s, has substantially declined during the last 10 years; a decline that was much steeper in comparison with expectation in subjects of similar ages. This study also suggests possible neurological and neurocognitive impacts of prenatal exposure to methylmercury among exposed residents of Minamata.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Remarks (1 results)

  • [Int'l Joint Research] University of Southern Denmark(デンマーク)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Temporal trends of infant and birth outcomes in Minamata after severe methylmercury exposure.2017

    • Author(s)
      Yorifuji T, Kashima S, Suryadhi MAH, Abudureyimu K.
    • Journal Title

      Environ Pollut.

      Volume: 231 (Pt 2) Pages: 1586-1592

    • DOI

      10.1016/j.envpol.2017.09.060

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 水俣病における胎児期メチル水銀曝露-見過ごされてきた胎児期低・中濃度曝露による神経認知機能の影響-2016

    • Author(s)
      頼藤貴志、入江佐織、加戸陽子、眞田敏
    • Journal Title

      環境と公害

      Volume: 46 (2) Pages: 52-58

    • Related Report
      2016 Research-status Report
  • [Journal Article] 胎児期メチル水銀曝露による神経認知機能:水俣病2016

    • Author(s)
      頼藤貴志、入江佐織、加戸陽子、眞田敏
    • Journal Title

      水俣学研究

      Volume: 7 Pages: 3-17

    • NAID

      40021039862

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Secondary sex ratio in regions severely exposed to methylmercury "Minamata disease".2016

    • Author(s)
      Takashi Yorifuji, Saori Kashima
    • Journal Title

      International Archives of Occupational and Environmental Health [Epub ahead of print]

      Volume: 89(4) Issue: 4 Pages: 659-665

    • DOI

      10.1007/s00420-015-1103-5

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neurological and Neurocognitive Functions from Intrauterine Methylmercury Exposure2015

    • Author(s)
      Takashi Yorifuji, Yoko Kado, Midory Higa Diez, Toshihiro Kishikawa, Satoshi Sanada
    • Journal Title

      Archives of Environmental and Occupational Health (published online)

      Volume: 24 Issue: 3 Pages: 1-6

    • DOI

      10.1080/19338244.2015.1080153

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Epidemiological studies of neurological signs and symptoms and blood pressure in populations near the industrial methylmercury contamination at Minamata, Japan2015

    • Author(s)
      Takashi Yorifuji, Toshihide Tsuda
    • Journal Title

      Archives of Environmental and Occupational Health (published online)

      Volume: 71 Issue: 4 Pages: 231-236

    • DOI

      10.1080/19338244.2015.1084261

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intrauterine Exposure to Methylmercury and Neurocognitive Functions - Minamata disease -2014

    • Author(s)
      Takashi Yorifuji, Tsuguhiko Kato, Yoko Kado, Akiko Tokinobu, Michiyo Yamakawa, Toshihide Tsuda, Satoshi Sanada
    • Journal Title

      Archives of Environmental and Occupational Health

      Volume: 未 Issue: 5 Pages: 297-302

    • DOI

      10.1080/19338244.2014.904268

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Remarks] 津田・頼藤研究室HP

    • URL

      http://www.okayama-u.ac.jp/user/envepi

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

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