Association between diffuse idiopathic skeletal hyperostosis, aprognosis nd vertebral fracture: population based cohort

• Project/Area Number: 26860419
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Wakayama Medical University
• Principal Investigator: Kagotani Ryohei 和歌山県立医科大学, 医学部, 学内助教 (00597081)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: びまん性特発性骨増殖症 / CTX-2 / 胸椎後弯 / 脊椎アライメント / 骨粗鬆症 / 一般住民コホート / 脊椎骨折 / 生活の質 / 予後

Outline of Final Research Achievements

This cross-sectional study was part of a large-scale population based Japanese cohort study named Research on Osteoarthritis/osteoporosis Against Disability (ROAD)from 2005-2007. Of the 1,690 inhabitants who underwent radiographic spinal examination, 1647 inhabitants (573 men and 1074 women, mean age 65.3 years) were finally included. The overall prevalence of DISH was 10.41% and was significantly higher in men (21.35% in men, 4.55% in women; p<0.0001). We clarified that DISH was related to CTX-Ⅱand thoracic hyperkyphosis using follo up survey.

Research Products

• [Journal Article] Prevalence of diffuse idiopathic skeletal hyperostosis (DISH) (2015)
  • Author(s): R.kagotani, M Yoshida et al
  • Journal Title: Journal of Bone and Mineral Metabolism Volume: 33 Pages: 221-229
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Sagittal Spinal Alignment and Balance in Diffuse Idiopathic Skeletal Hyperostosis: A population based Cohort Study (2016)
  • Author(s): 籠谷
  • Organizer: American Academy of Orthopaedic Surgeons
  • Place of Presentation: オーランド(アメリカ)
  • Year and Date: 2016-03-01
  • Int'l Joint Research
• [Presentation] びまん性特発性骨増殖症と骨密度及びCTX-Ⅱとの関連:population-based cohort (2015)
  • Author(s): 籠谷 良平
  • Organizer: 第88回日本整形外科学会学術集会
  • Place of Presentation: 神戸市
  • Year and Date: 2015-05-21
• [Presentation] びまん性特発性骨増殖症とQOLとの関係 (2015)
  • Author(s): 籠谷 良平
  • Organizer: 第44回脊椎脊髄病学会
  • Place of Presentation: 福岡市
  • Year and Date: 2015-04-16
• [Presentation] Association between diffuse idiopathic skeletal hyperostosis, bone mineral density, and CTX2:The ROAD study (2015)
  • Author(s): 籠谷
  • Organizer: American Academy of Orthopaedic Surgeons
  • Place of Presentation: ラスヴェガス（アメリカ）
  • Year and Date: 2015-03-24 – 2015-03-28
• [Presentation] びまん性特発性骨増殖症と変形性腰椎症及び変形性膝関節症との関連: (2014)
  • Author(s): 籠谷 良平
  • Organizer: 第29回日本整形外科学会基礎学術集会
  • Place of Presentation: 鹿児島市
  • Year and Date: 2014-10-09 – 2015-10-10
• [Presentation] Prevalence of diffuse idiopathic skeletal hyperostosis and its association with lumbar spondylosis and knee osteoarthritis: population-based cohort (2014)
  • Author(s): 籠谷 良平
  • Organizer: 第８７回日本整形外科学会学術集会
  • Place of Presentation: 神戸市
  • Year and Date: 2014-05-22 – 2014-05-25
• [Presentation] Prevalence of diffuse idiopathic skeletal hyperostosis and its association with lumbar spondylosis and knee osteoarthritis: population-based cohort (2014)
  • Author(s): 籠谷 良平
  • Organizer: 第４３回日本脊椎脊髄病学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2014-04-17 – 2014-04-19