Exploration of lifestyle and psycho-social factors associated with prognosis of patients with gastric cancer

• Project/Area Number: 26860430
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: Oze Isao 愛知県がんセンター(研究所), 疫学・予防部, 主任研究員 (00584509)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 胃がん / がんサバイバー / コホート研究 / 臨床疫学研究 / 胃がんサバイバー

Outline of Final Research Achievements

Lifestyle factors, social factors and psychological factors were not evaluated for the effect of prognosis in patients with gastric cancer. We conducted the cohort study of gastric cancer survivors. Study subjects were patients who underwent first line therapy for gastric cancer in Aichi Cancer Center Hospital. The cohort study begun on January 2015. 243 gastric cancer survivors participated in the study by March 2017.
We conducted the cross-sectional study to evaluate the applicability of miR-104, miR-107 and miR-194 to screening for human diffuse gastric cancer. Three plasma miRNAs from 50 gastric cancer cases and 50 non-cancer controls were evaluated, however, none of them were applicable for diffuse gastric cancer screening.

Research Products

• [Journal Article] Plasma microRNA-103, microRNA-107, and microRNA-194 levels are not biomarkers for human diffuse gastric cancer. (2017)
  • Author(s): Oze I, Shimada S, Nagasaki H, Akiyama Y, Watanabe M, Yatabe Y, Matsuo K, Yuasa Y.
  • Journal Title: J Cancer Res Clin Oncol Volume: 143 Issue: 3 Pages: 551-554
  • DOI: 10.1007/s00432-016-2316-z
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 咽頭がん・食道がんの疫学とリスク因子 (2016)
  • Author(s): 尾瀬功 伊藤秀美 松尾恵太郎
  • Journal Title: 消化器内視鏡 Volume: 28 Pages: 36-41
• [Journal Article] Coffee and green tea consumption is associated with upper aerodigestive tract cancer in Japan (2014)
  • Author(s): Oze I, Matsuo K, Kawakita D, Hosono S, Ito H, Watanabe M, Hatooka S, Hasegawa Y, Shinoda M, Tajima K, Tanaka H.
  • Journal Title: International journal of cancer Volume: 135 Issue: 2 Pages: 391-400
  • DOI: 10.1002/ijc.28653
  • Peer Reviewed
• [Presentation] 愛知県がんセンター胃がん・大腸がんサバイバーコホート研究 (2016)
  • Author(s): 尾瀬功、細野覚代、渡邉美貴、伊藤秀美、松尾恵太郎、伊藤誠二、田中努、田中英夫
  • Organizer: がん予防学術大会2016名古屋
  • Place of Presentation: 名古屋大学（名古屋市）
  • Year and Date: 2016-07-01