Investigation on molecular epidemiology and clinical features of diarrheal viruses including emerging strains in Indonesia
| Project/Area Number |
26860434
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAKANASHI Sayaka 東京大学, 大学院医学系研究科(医学部), 助教 (20645709)
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| Co-Investigator(Renkei-kenkyūsha) |
USHIJIMA Hiroshi 日本大学, 医学部, 上席研究員 (10091068)
OKITSU Shoko 日本大学, 医学部, 客員研究員 (10082215)
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| Research Collaborator |
KALESARAN Angela
THONGPRACHUM Aksara
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 急性胃腸炎 / ロタウイルス / ノロウイルス / 小児 / インドネシア / 分子疫学 / 入院例 / 小児急性胃腸炎 |
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| Outline of Final Research Achievements |
Four hundred and forty one fecal specimens were collected from hospitalized pediatric patients and screened for diarrheal viruses by RT-PCR. Nine target viruses were detected in 262 out of 441 (59.4%) samples. Group A rotavirus (59.5%), followed by norovirus GII (16.4%), were the most predominant viral agents. Other viruses such as astrovirus (3.8%), sapovirus (2.7%), human parechovirus (2.7%), enterovirus (2.3%), adenovirus (2%), norovirus GI(1.1%), and Aichi virus (0.2%) were also detected. Rotavirus cases were found throughout the year, with two peaks in April and September. G1P[8] strain was the most prevalent (69.5%) G-P combination, followed by G3P[8] (16.8%). This study confirmed the diversity of viruses causing acute gastroenteritis among pediatric patients in Indonesia, with group A rotavirus being the most predominant viral agents. They emphasize the importance of introducing rotavirus vaccines in Indonesian children as a prevention strategy to reduce the disease burden.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Molecular epidemiological traits of group A rotaviruses in Japanese children during transitional period of rotavirus vaccine implementation, 2011-2014.2017
Author(s)
Takanashi S, Thongprachum A, Okitsu S, Nishimura S, Kobayashi M, Kikuta H, Yamamoto A, Sugita K, Baba T, Hayakawa S, Mizuguchi M, Ushijima H
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Journal Title
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Cosavirus (family Picornaviridae) in pigs in Thailand and Japan2016
Author(s)
Okitsu S, Khamrin P, Hanaoka N, Thongprachum A, Takanashi S, Fujimoto T, Mizuguchi M, Shimizu H, Hayakawa S, Maneekarn N, Ushijima H
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Journal Title
Arch Virol
Volume: 161
Issue: 1
Pages: 159-163
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Cosavirus (family Picornaviridae) in pigs in Thailand and Japan.2016
Author(s)
Okitsu S, Khamrin P, Hanaoka N, Thongprachum A, Takanashi S, Fujimoto T, Mizuguchi M, Shimizu H, Hayakawa S, Maneekarn N, Ushijima H.
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Journal Title
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Circulating rotavirus in hospitalized pediatric patients, with the predominance of G1P[8]DS-1-like human rotavirus in Manado, Indonesia.2014
Author(s)
Kalesaran AFC, Thongprachum A, Pangemanan DHC, Takanashi S, Okitsu S, Hayakawa S, Warouw SM, Mizuguchi M, Ushijima H.
Organizer
International Meeting on Emerging Diseases and Suiveillance 2014
Place of Presentation
Hilton Vienna （オーストリア、ウイーン市）
Year and Date
2014-10-31 – 2014-11-03
Related Report
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