| Project/Area Number |
26860434
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAKANASHI Sayaka 東京大学, 大学院医学系研究科(医学部), 助教 (20645709)
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| Co-Investigator(Renkei-kenkyūsha) |
USHIJIMA Hiroshi 日本大学, 医学部, 上席研究員 (10091068)
OKITSU Shoko 日本大学, 医学部, 客員研究員 (10082215)
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| Research Collaborator |
KALESARAN Angela
THONGPRACHUM Aksara
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 急性胃腸炎 / ロタウイルス / ノロウイルス / 小児 / インドネシア / 分子疫学 / 入院例 / 小児急性胃腸炎 |
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| Outline of Final Research Achievements |
Four hundred and forty one fecal specimens were collected from hospitalized pediatric patients and screened for diarrheal viruses by RT-PCR. Nine target viruses were detected in 262 out of 441 (59.4%) samples. Group A rotavirus (59.5%), followed by norovirus GII (16.4%), were the most predominant viral agents. Other viruses such as astrovirus (3.8%), sapovirus (2.7%), human parechovirus (2.7%), enterovirus (2.3%), adenovirus (2%), norovirus GI(1.1%), and Aichi virus (0.2%) were also detected. Rotavirus cases were found throughout the year, with two peaks in April and September. G1P[8] strain was the most prevalent (69.5%) G-P combination, followed by G3P[8] (16.8%). This study confirmed the diversity of viruses causing acute gastroenteritis among pediatric patients in Indonesia, with group A rotavirus being the most predominant viral agents. They emphasize the importance of introducing rotavirus vaccines in Indonesian children as a prevention strategy to reduce the disease burden.
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