The effect of lead on the developmental process of the nervous system and its sexual difference
| Project/Area Number |
26860444
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | Kitasato University (2016)
Juntendo University (2014-2015) |
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Principal Investigator |
Omori Yuki 北里大学, 医学部, 助教 (30415971)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 鉛 / 神経毒性 / アストロサイト / カルシウム応答 / D-Serine / D-セリン / カルシウムイオン |
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| Outline of Final Research Achievements |
We studied the influence of calcium signaling in rat hippocampus astrocytes after exposure to lead. There was the tendency to decrease calcium ion influx into astrocytes with concentration-dependent lead exposure and to become slower than control. Moreover, we observed increase of D,L-Serine in 40 μM lead exposure astrocytes. This study suggested that Astrocyte is possibly one of the pathway in the lead-induced neurotoxicity.
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Report
(4 results)
Research Products
(2 results)
