The effect of lead on the developmental process of the nervous system and its sexual difference

Research Project

Project/Area Number	26860444
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Hygiene and public health
Research Institution	Kitasato University (2016) Juntendo University (2014-2015)
Principal Investigator	Omori Yuki 北里大学, 医学部, 助教 (30415971)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	鉛 / 神経毒性 / アストロサイト / カルシウム応答 / D-Serine / D-セリン / カルシウムイオン
Outline of Final Research Achievements	We studied the influence of calcium signaling in rat hippocampus astrocytes after exposure to lead. There was the tendency to decrease calcium ion influx into astrocytes with concentration-dependent lead exposure and to become slower than control. Moreover, we observed increase of D,L-Serine in 40 μM lead exposure astrocytes. This study suggested that Astrocyte is possibly one of the pathway in the lead-induced neurotoxicity.

Report

(4 results)