Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Outline of Final Research Achievements |
We studied the influence of calcium signaling in rat hippocampus astrocytes after exposure to lead. There was the tendency to decrease calcium ion influx into astrocytes with concentration-dependent lead exposure and to become slower than control. Moreover, we observed increase of D,L-Serine in 40 μM lead exposure astrocytes. This study suggested that Astrocyte is possibly one of the pathway in the lead-induced neurotoxicity.
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