Screening and toxic evaluation of the allergic induction and/or exacerbation substance using hybrid-hybrid screening system
| Project/Area Number |
26860447
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | Setsunan University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アレルギー応答 / 免疫応答 |
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| Outline of Final Research Achievements |
It is suggested that the immune diseases such as allergies causes it with the disruption of epithelial cell barrier. In this study, we performed the basic data for development of the hybrid detection system that could evaluate the barrier function and the immune response by an environmental pollution at the same time. It was observed that various environmental pollutants were decreased barrier function, and disrupted the immune response. There results suggest the possibility to develop the hybrid detection system that could evaluate the barrier function and the immune response by an environmental pollution at the same time.
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] Facilitation of adipocyte differentiation of 3T3-L1 cells by debrominated tetrabromobisphenol A compounds detected in Japanese breast milk2015
Author(s)
Akiyama, E., Kakutani, H., Nakao, T., Motomura, Y., Takano, Y., Sorakubo, R., Mizuno, A., Aozasa, O., Tachibana, K., Doi, T., Ohta, S.
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Journal Title
Environmenta Research
Volume: 140
Pages: 157-164
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Levels of tetrabromobisphenol A, tribromobisphenol A, dibromobisphenol A, monobromobisphenol A, and bisphenol A in Japanese breast milk.2015
Author(s)
Nakao, T., Akiyama, E., Kakutani, H., Mizuno, A., Aozasa, O., Akai, Y., Ohta, S.
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Journal Title
Chemical Research in Toxicology
Volume: 28
Issue: 4
Pages: 722-728
DOI
Related Report
Peer Reviewed
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[Journal Article] In vitro and in vivo induction of cytochrome P450 by coplanar polychlorinated/brominated biphenyls (Co-PXBs) providing high TEQ in mother’s milk in Japan.2014
Author(s)
Akiyama, E., Kakutani, H., Nakao, T., Motomura, Y., Takano, Y., Sorakubo, R., Mizuno, A., Aozasa, O., Tachibana, K., Doi, T., Ohta, S.
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Journal Title
Toxicology
Volume: 324
Pages: 157-164
DOI
Related Report
Peer Reviewed
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