One of the functional analysis for RNA-binding motif protein 3 in Vitro
| Project/Area Number |
26860464
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
MORITA SATOMU 滋賀医科大学, 医学部, 非常勤講師 (80721894)
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| Co-Investigator(Renkei-kenkyūsha) |
MORITA Rihito 岡山理科大学, 理学部, 助教 (10613268)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | RBM3の機能解析 / RBM3の翻訳抑制 / RBM3 / 低酸素 |
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| Outline of Final Research Achievements |
We previously reported that RBM3 in the myocardium using immunohistochemical staining, and the appearance patterns changed by environment of agonal phase. We investigated the function of RBM3 in Vitro.
Our results was different from previous in Vivo investigations. Our results from the in Vitro cell-free translation system showed that RBM3 inhibits translation. These findings suggest that the increase in global translation is due to the effect on miRNA processing and that inhibition of translation has little effect in Vivo.
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Report
(4 results)
Research Products
(10 results)
