| Project/Area Number |
26860466
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Research Collaborator |
LIU Jinyao 山口大学, 大学院医学系研究科, 講師 (60379956)
FUJIMIYA Tatsuya 山口大学, 大学院医学系研究科, 教授 (50219044)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | アルコール性肝障害 / 高血圧 / 交感神経系 / 高血圧自然発症ラット / 肝星細胞 / 慢性飲酒 / SHR |
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| Outline of Final Research Achievements |
We examined the effects of hypertension on the progression of alcoholic liver injury using the spontaneously hypertensive rat (SHR) and normotensive Wistar-Kyoto rat (WKY) as control. As a result, chronic ethanol treatment in SHR induced hepatosteatosis with liver injury and sympathetic hyperactivity, as evidenced by increased in the accumulation of fatty droplets within hepatocytes and pericellular hepatic fibrosis with liver injury, increased in gene or protein expressions such as activated hepatic stellate cells, TNF-α, TGF-β1,collagen, adrenergic α receptor, neuropeptide Y and tyrosine hydroxylase. These results suggested that chronic ethanol treatment in SHR could induce the more severe liver injuries. In conclusion, chronic alcohol intake and hypertension could be possible to deteriorate mutually each pathological state via the sympathetic overactivity.
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