Investigation of relationship between dopamine signaling and endocannabinoid system
| Project/Area Number |
26860471
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | Fujita Health University |
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Principal Investigator |
Ochi Hiroshi 藤田保健衛生大学, 医学部, 助教 (70527704)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 内因性カンナビノイド / 内因性カンナビノイドシステム / ドーパミン / グリア細胞 / C6 / 薬物依存 / PC12 |
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| Outline of Final Research Achievements |
In the central nervous system, endocannabinoids are released from postsynaptic neuron, and retrogradely act on the receptors on the presynaptic membrane to inhibit neurotransmitter release from presynaptic neuron. In this study, we revealed that mRNA level of PLCβ4 (2-AG synthetic enzyme) was up-regulated and mRNA level of MGLL (2-AG degrading enzyme) was down-regulated by dopamine treatment. Thereby 2-AG signaling of glial cell was enhanced. From these results, under the condition that dopamine concentration rises for a long term at the synapse, it is suggested that glial endocannabinoid system is involved in the regulation of the dopamine signaling.
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Report
(4 results)
Research Products
(3 results)
