| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
In the central nervous system, endocannabinoids are released from postsynaptic neuron, and retrogradely act on the receptors on the presynaptic membrane to inhibit neurotransmitter release from presynaptic neuron. In this study, we revealed that mRNA level of PLCβ4 (2-AG synthetic enzyme) was up-regulated and mRNA level of MGLL (2-AG degrading enzyme) was down-regulated by dopamine treatment. Thereby 2-AG signaling of glial cell was enhanced. From these results, under the condition that dopamine concentration rises for a long term at the synapse, it is suggested that glial endocannabinoid system is involved in the regulation of the dopamine signaling.
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