Elucidation of common mechanism for the development of metabolic and locomotive syndrome

• Project/Area Number: 26860489
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Keio University
• Principal Investigator: HIRATA TAKUMI 慶應義塾大学, 医学部(信濃町), 特任助教 (00383795)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 骨代謝マーカー / 骨密度 / インスリン抵抗性 / 高分子量アディポネクチン / 肥満 / 疫学研究 / 骨粗鬆症 / やせ / アディポネクチン / 体重 / コホート研究 / 骨型アルカリホスファターゼ / 酒石酸抵抗性酸ホスファターゼ5b

Outline of Final Research Achievements

We clarified the association between various factors related to metabolic syndrome and bone mineral density or markers for bone metabolism. Neither insulin resistance nor high-molecular-weight adiponectin level was significantly associated with bone mineral density, and body mass index was strongly confounded these associations in men and postmenopausal women. Marker levels for bone metabolism, such as BAP or TRACP-5b, decreased in order of postmenopausal women, men, and premenopausal women. TRACP-5b levels, marker for bone absorption, were increased with age in men and premenopausal women, but TRACP-5b levels were decreased in postmenopausal women with over 70 years. On the other hand, BAP levels, marker for bone formation, were decreased with age in postmenopausal women. In addition, BAP levels were significantly higher in obese participants irrespective of gender and menopausal status, and TRACP-5b levels were significantly lower in postmenopausal obese women.

Research Products

• [Journal Article] Underweight Young Women Without Later Weight Gain Are at High Risk for Osteopenia After Midlife: The KOBE Study (2016)
  • Author(s): Yukako Tatsumi, Aya Higashiyama, Yoshimi Kubota, Daisuke Sugiyama, Yoko Nishida, Takumi Hirata, Aya Kadota, Kunihiro Nishimura, Hironori Imano, Naomi Miyamatsu, Yoshihiro Miyamoto, Tomonori Okamura
  • Journal Title: Journal of Epidemiology Volume: 26 Issue: 11 Pages: 572-578
  • DOI: 10.2188/jea.JE20150267
  • NAID: 130005278969
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 女性における20歳時及び40-75歳時のBody mass indexと骨密度の関連：神戸トライアル (2015)
  • Author(s): 7)辰巳 友佳子, 東山 綾, 久保田 芳美, 杉山 大典, 西田 陽子, 平田 匠, 門田 文, 西村 邦宏, 今野 弘規, 宮松 直美, 宮本 恵宏, 岡村 智教
  • Organizer: 第74回日本公衆衛生学会年次学術集会
  • Place of Presentation: 長崎新聞文化ホール（長崎県長崎市）
  • Year and Date: 2015-11-04
• [Presentation] 高分子量アディポネクチンと骨密度の関連はBMIにより交絡する：神戸研究 (2015)
  • Author(s): 平田 匠, 東山 綾, 久保田 芳美, 西村 邦宏, 杉山 大典, 門田 文, 西田 陽子, 今野 弘規, 西川 智文, 宮松 直美, 宮本 恵宏, 岡村 智教
  • Organizer: 第33回日本肥満症治療学会
  • Place of Presentation: 幕張国際研修センター（千葉県千葉市美浜区）
  • Year and Date: 2015-06-27