| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We clarified the association between various factors related to metabolic syndrome and bone mineral density or markers for bone metabolism. Neither insulin resistance nor high-molecular-weight adiponectin level was significantly associated with bone mineral density, and body mass index was strongly confounded these associations in men and postmenopausal women. Marker levels for bone metabolism, such as BAP or TRACP-5b, decreased in order of postmenopausal women, men, and premenopausal women. TRACP-5b levels, marker for bone absorption, were increased with age in men and premenopausal women, but TRACP-5b levels were decreased in postmenopausal women with over 70 years. On the other hand, BAP levels, marker for bone formation, were decreased with age in postmenopausal women. In addition, BAP levels were significantly higher in obese participants irrespective of gender and menopausal status, and TRACP-5b levels were significantly lower in postmenopausal obese women.
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