| Project/Area Number |
26860490
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
Ueno Nobuhiro 旭川医科大学, 医学部, 助教 (30436000)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | プロバイオティクス / 過敏性腸症候群 / 腸内細菌叢 / ポリリン酸 / 腸内細菌 |
|---|
| Outline of Final Research Achievements |
In this study, we investigated the alteration of microbiota of mice and the efficacy for the treatment of IBS model mice by the oral administration of heat-killed of L.brevis SB88. In result, heat-killed of L. brevis SB88 altered the microbiota of SPF mice after 28days oral administration. And it suppressed the expression of inflammatory cytokine of the epithelium cells in mice intestine, especially the mice which has been altered microbiota. Although it does not have strong effect for the IBS model mice.
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