Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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Outline of Final Research Achievements |
Hepatitis B virus (HBV) can cause chronic infection in the liver. It can lead to chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Cellular aging may be associated with HBV-related liver diseases. Knockdown of sirtuins, genes associated with age-related diseases, was associated with the activity of hepatic stellate cell. HBV replication altered the activity of hepatic stellate cell. Cellular aging assay suggested that X protein expression may have a potential to alter cellular aging. Lack of sirtuin using CRISPR/Cas system affected HBV replication. The results suggested that sirtuin may have a role in HBV-related liver disease.
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