Contribution of TET1 to a malignant phenotype in digestive cancer cells.
Project/Area Number |
26860494
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
|
Research Institution | The University of Tokyo |
Principal Investigator |
Kudo Yotaro 東京大学, 医学部附属病院, 助教 (90608358)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | DNA脱メチル化 / 有糸分裂異常 / 消化器がん / TET1 |
Outline of Final Research Achievements |
TET family proteins initiate the DNA demethylation process (Tahiliani M. Science 2009, Ito S. Nature 2010, Ito S. Science 2011, He YF. Science 2011). Our previous study indicated that DNA demethylation was involved in biological properties of cancer cells. In this study, we tried to shed light on the roles of TET1 in cancer cells. TET1-knocked down cancer cells were subjected to genomic methylation analysis, expression analysis, and chromatin immunoprecipitation analysis. TET1 depletion reduced the binding of TET1 protein to the mitotic genes following to the enhanced methylation of these genes, finally resulting in impaired mitosis and impaired proliferation of cancer cells.
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Report
(3 results)
Research Products
(3 results)
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[Presentation] TET1 regulates proper mitotic process in cancer cell.2015
Author(s)
Yotaro Kudo, Keisuke Tateishi, Genta Nagae, Takuma Nakatsuka, Keisuke Yamamoto, Yoshinari Asaoka, Yasuo Tanaka, Tsuneo Ikenoue, Kiyokazu Shirai, Masato Yonezawa, Motoaki Seki, Hiroyuki Aburatani, Kazuhiko Koike
Organizer
The 73rd Annual Meeting of the Japanese Cancer Association
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2015-09-25 – 2015-09-27
Related Report
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[Presentation] 消化器癌におけるDNA脱メチル化酵素TET1の役割の検討2015
Author(s)
工藤洋太郎, 立石敬介, 永江玄太, 山本恵介, 中塚拓馬, 浅岡良成, 田中康雄, 池上恒雄, 白井聖一, 関元昭, 米沢理人, 油谷浩幸, 小池和彦
Organizer
第101回日本消化器病学会総会
Place of Presentation
仙台国際センター(宮城県仙台市)
Year and Date
2015-04-23 – 2015-04-25
Related Report
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[Presentation] 消化器癌におけるDNA脱メチル化酵素TET1の役割の検討2015
Author(s)
工藤洋太郎,立石敬介,永江玄太,山本恵介,中塚拓馬,浅岡良成,田中康雄,池上恒雄,白井聖一,関元昭,米沢理人,油谷浩幸,小池和彦
Organizer
第101回日本消化器病学会総会
Place of Presentation
仙台国際センター
Year and Date
2015-04-23
Related Report