Molecular mechanism of gastric carcinogenesis through restricted dedifferentiation by Helicobacter pylori CagA

Research Project

Project/Area Number	26860495
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Gastroenterology
Research Institution	The University of Tokyo
Principal Investigator	FUJII YUMIKO 東京大学, 医学(系)研究科(研究院), 特任助教 (30722334)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	ヘリコバクター・ピロリ / 化生
Outline of Final Research Achievements	Chronic infection with cagA-positive Helicobacter pylori is associated with gastric diseases including gastritis, metaplasia and carcinoma. In this project, we demonstrated that CagA protein induces precancerous mucosal lesion defined as spasmolytic polypeptide expressing metaplasia (SPEM) in mouse gastric corpus. We also found that CagA deregulates the phosphorylation status of the E-cadherin cytoplasmic domain in gastric epithelial cells.

Report

(3 results)