Relationship between non-alcoholic fatty liver disease and hepatic retinoid signaling

• Project/Area Number: 26860498
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Gifu University
• Principal Investigator: Shirakami Yohei 岐阜大学, 医学(系)研究科(研究院), 助教 (50632816)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: レチノイド / 脂肪肝 / インスリン抵抗性 / NASH / 糖代謝

Outline of Final Research Achievements

The phenotype of transgenic mice (dnRXR mice) whose retinoid X receptor (RXR) signaling is inhibited in a dominant negative manner was investigated. The mice exhibited significantly impaired glucose tolerance when they were fed high-fat diet. The mice also showed marked hepatic steatosis and liver injury in both drug- and diet-induced obesity models. These results suggest that dnRXR mice present glucose intolerance and steatohepatitis due to the stimulation to induce obesity, indicating RXR signaling may play a role in glucose metabolism and hepatic steatosis.

Research Products

• [Journal Article] Chemoprevention of obesity-related liver carcinogenesis by using pharmaceutical and nutraceutical agents. (2016)
  • Author(s): Sakai H, Shirakami Y, Shimizu M.
  • Journal Title: World J Gastroenterol Volume: 22(1) Issue: 1 Pages: 394-406
  • DOI: 10.3748/wjg.v22.i1.394
  • Peer Reviewed / Open Access
• [Journal Article] Preventive effects of astaxanthin on diethylnitrosamine-induced liver tumorigenesis in C57/BL/KsJ-db/db obese mice. (2016)
  • Author(s): Ohno T, Shimizu M, Shirakami Y, Miyazaki T, Ideta T, Kochi T, Kubota M, Sakai H, Tanaka T, Moriwaki H.
  • Journal Title: Hepatol Res. Volume: 46(3) Issue: 3 Pages: 201-209
  • DOI: 10.1111/hepr.12550
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Metabolome Analyses Uncovered a Novel Inhibitory Effect of Acyclic Retinoid on Aberrant Lipogenesis in a Mouse Diethylnitrosamine-Induced Hepatic Tumorigenesis Model. (2016)
  • Author(s): Qin, X-Y., Tatsukawa, H., hitomi, K., Shirakami, Y., Ishibashi, N., Shimizu, M., Moriwaki, H., and *Kojima, S.
  • Journal Title: Cancer Prevention Res. Volume: 9(3) Issue: 3 Pages: 205-214
  • DOI: 10.1158/1940-6207.capr-15-0326
  • Peer Reviewed
• [Journal Article] Sodium alginate prevents progression of non-alcoholic steatohepatitis and liver carcinogenesis in obese and diabetic mice. (2016)
  • Author(s): Miyazaki T, Shirakami Y, Kubota M, Ideta T, Kochi T, Sakai H, Tanaka T, Moriwaki H, Shimizu M.
  • Journal Title: Oncotarget Volume: - Issue: 9 Pages: 10448-10458
  • DOI: 10.18632/oncotarget.7249
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cimetidine and Clobenpropit Attenuate Inflammation-Associated Colorectal Carcinogenesis in Male ICR Mice (2016)
  • Author(s): Tanaka T, Kochi T, Shirakami Y, Mori T, Kurata A, Watanabe N, Moriwaki H, Shimizu M
  • Journal Title: Cancers Volume: 8 Issue: 2 Pages: 25-25
  • DOI: 10.3390/cancers8020025
  • Peer Reviewed
• [Journal Article] Metformin suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-+Leprdb/+Leprdb mice. (2015)
  • Author(s): Shimizu M, Ohno T, Shirakami Y, Baba A, Kochi T, Kubota M, Tsurumi H, Tanaka T, Moriwaki H.
  • Journal Title: PLoS One Volume: 10 Issue: 4 Pages: e0124081-e0124081
  • DOI: 10.1371/journal.pone.0124081
  • Peer Reviewed / Open Access
• [Journal Article] Utility of Apc-mutant rats with a colitis-associated colon carcinogenesis model for chemoprevention studies. (2015)
  • Author(s): Kochi T, Shimizu M, Shirakami Y, Yoshimi K, Kuramoto T, Tanaka T, Moriwaki H.
  • Journal Title: Eur J Cancer Prev Volume: 24 Issue: 3 Pages: 180-187
  • DOI: 10.1097/cej.0000000000000063
  • Peer Reviewed
• [Journal Article] Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice. (2015)
  • Author(s): Nakamura N, Hara T, Shimizu M, Mabuchi R, Nagano J, Ohno T, Kochi T, Kubota M, Shirakami Y, Goto N, Ito H, Saito K, Tanaka T, Moriwaki H, Tsurumi H.
  • Journal Title: Int J Hematol Volume: 102 Issue: 3 Pages: 327-334
  • DOI: 10.1007/s12185-015-1835-8
  • Peer Reviewed
• [Journal Article] Chemopreventive potential of green tea catechins in hepatocellular carcinoma. (2015)
  • Author(s): Shimizu M, Shirakami Y, Sakai H, Kubota M, Kochi T, Ideta T, Miyazaki T, Moriwaki H.
  • Journal Title: Int J Mol Sci. Volume: 16(3) Issue: 3 Pages: 6124-6139
  • DOI: 10.3390/ijms16036124
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Retinoid roles in blocking hepatocellular carcinoma. (2015)
  • Author(s): Shirakami Y，Sakai H, Shimizu M.
  • Journal Title: Hepatobilliary Surg Nutr Volume: 4 Pages: 222-228
  • Peer Reviewed
• [Journal Article] 新規肝線維化マーカー「Mac-2 binding protein 糖鎖修飾異性体（M2BPGi）」のＣ型肝炎に対するペグインターフェロン・リバビリン併用療法による変化 (2015)
  • Author(s): 石田秀和，末次 淳，中村真大，田内里奈，中山純里，片野由里子，古田伸行，白上洋平，伊藤弘康，清島 満．
  • Journal Title: 臨床病理 Volume: 63 Pages: 901-906
• [Journal Article] The Dipeptidyl Peptidase-4 Inhibitor Teneligliptin Attenuates Hepatic Lipogenesis via AMPK Activation in Non-Alcoholic Fatty Liver Disease Model Mice. (2015)
  • Author(s): Ideta T, Shirakami Y, Miyazaki T, Kochi T, Sakai H, Moriwaki H, Shimizu M.
  • Journal Title: Int J Mol Sci. Volume: 16(12) Issue: 12 Pages: 29207-29218
  • DOI: 10.3390/ijms161226156
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pentoxifylline prevents non-alcoholic steatohepatitis-related liver pre-neoplasms by inhibiting hepatic inflammation and lipogenesis. (2015)
  • Author(s): Shirakami Y, Shimizu M, Kubota M, Ohno T, Kochi T, Nakamura N, Sumi T, Tanaka T, Moriwaki H, Seishima M.
  • Journal Title: Eur J Cancer Prev Volume: 25 Issue: 3 Pages: 206-215
  • DOI: 10.1097/cej.0000000000000172
  • Peer Reviewed
• [Journal Article] Chemopreventive Potential of Green Tea Catechins in Hepatocellular Carcinoma. (2015)
  • Author(s): Shimizu M, Shirakami Y, Sakai H, Kubota M, Kochi T, Ideta T, Miyazaki T, Moriwaki H.
  • Journal Title: Int J Mol Sci Volume: 16 Pages: 6124-6139
  • Peer Reviewed
• [Journal Article] A newly synthesized compound, 4'-geranyloxyferulic acid-N(omega)-nitro-l-arginine methyl ester suppresses inflammation-associated colorectal carcinogenesis in male mice. (2014)
  • Author(s): Shimizu M, Kochi T, Shirakami Y, Genovese S, Epifano F, Fiorito S, Mori T, Tanaka T, Moriwaki H.
  • Journal Title: Int J Cancer Volume: 135 Issue: 4 Pages: 774-784
  • DOI: 10.1002/ijc.28718
  • Peer Reviewed
• [Journal Article] Combination of Bevacizumab and Acyclic Retinoid Inhibits the Growth of Hepatocellular Carcinoma Xenografts (2014)
  • Author(s): Kubota M, Shimizu M, Baba A, Ohno T, Kochi T, Shirakami Y, Moriwaki H.
  • Journal Title: Journal of Nutritional Science and Vitaminology Volume: 60 Issue: 5 Pages: 357-362
  • DOI: 10.3177/jnsv.60.357
  • NAID: 130004773635
  • ISSN: 0301-4800, 1881-7742
  • Peer Reviewed
• [Journal Article] Preventive effects of captopril, an angiotensin-converting enzyme inhibitor, on the development of azoxymethane-induced colonic preneoplastic lesions in diabetic and hypertensive rats. (2014)
  • Author(s): Kochi T, Shimizu M, Ohno T, Baba A, Sumi T, Kubota M, Shirakami Y, Tsurumi H, Tanaka T, Moriwaki H.
  • Journal Title: Oncol Lett Volume: 8 Pages: 223-229
  • Peer Reviewed
• [Journal Article] A novel aromatic mutagen, 5-amino-6-hydroxy-8H-benzo [6,7] azepino [5,4,3-de] quinolin-7-one (ABAQ), induces colonic preneoplastic lesions in mice. (2014)
  • Author(s): Kochi T, Shimizu M, Totsuka Y, Shirakami Y, Nakanishi T, Watanabe T, Tanaka T, Nakagama H, Wakabayashi K, Moriwaki H.
  • Journal Title: Toxicology Rep Volume: 1 Pages: 69-73
  • Peer Reviewed
• [Journal Article] Apc-mutant Kyoto Apc Delta (KAD) rats are susceptible to 4-NQO-induced tongue carcinogenesis. (2014)
  • Author(s): Tanaka T, Shimizu M, Kochi T, Shirakami Y, Mori T, Watanabe N, Naiki T, Moriwaki H, Yoshimi K, Serikawa T, Kuramoto T.
  • Journal Title: Cancers Volume: 6 Pages: 1522-1539
  • Peer Reviewed
• [Journal Article] Pharmaceutical and nutraceutical approaches for preventing liver carcinogenesis: chemoprevention of hepatocellular carcinoma using acyclic retinoid and branched-chain amino acids. (2014)
  • Author(s): Shimizu M, Shirakami Y, Hanai T, Imai K, Suetsugu A, Takai K, Shiraki M, Moriwaki H.
  • Journal Title: Mol Nutr Food Res. Volume: 58 Issue: 1 Pages: 124-135
  • DOI: 10.1002/mnfr.201300538
  • Peer Reviewed
• [Journal Article] Chemoprevention of colorectal cancer by targeting obesity-related metabolic abnormalities. (2014)
  • Author(s): Shirakami Y, Shimizu M, Kubota M, Araki H, Tanaka T, Moriwaki H, Seishima M.
  • Journal Title: World J Gastroenterol Volume: 20 Pages: 8939-8946
  • Peer Reviewed
• [Journal Article] Inhibitory effects of astaxanthin on azoxymethane-induced colonic preneoplastic lesions in C57/BL/KsJ- db/db mice. BMC Gastroenterol. (2014)
  • Author(s): Kochi T, Shimizu M, Sumi T, Kubota M, Shirakami Y, Tanaka T, Moriwaki H.
  • Journal Title: BMC Gastroenterol Volume: 14 Pages: 212-212
  • Peer Reviewed / Open Access
• [Journal Article] 哺乳類ラパマイシン標的たんぱく質経路 (2014)
  • Author(s): 白上洋平，清水雅仁．
  • Journal Title: 栄養―評価と治療 Volume: 31 Pages: 230-233
• [Presentation] 非アルコール性脂肪肝炎モデルにおいてDPP4阻害薬テネグリプチンは肝脂肪化を抑制する (2015)
  • Author(s): 白上洋平、岩佐将充、伊藤弘康、清島 満
  • Organizer: 第62回日本臨床検査医学会学術集会
  • Place of Presentation: 岐阜
  • Year and Date: 2015-11-20
• [Presentation] Effects of a synthetic retinoid on hepatitis B virus. (2015)
  • Author(s): Shirakami Y, Maruta A, Obara K, Ideta T, Miyazaki T, Sakai H, Shimizu M, Seishima M.
  • Organizer: The 3rd International Conference on Retinoids
  • Place of Presentation: 岐阜
  • Year and Date: 2015-10-21
  • Int'l Joint Research
• [Presentation] The role of the phosphorylated RXR-alpha on diethylnitrosamine-induced liver tumorigenesis in mice. (2015)
  • Author(s): Sakai H, Yamada Y, Shirakami Y, Hara A, Shimizu M.
  • Organizer: The 3rd International Conference on Retinoids
  • Place of Presentation: 岐阜
  • Year and Date: 2015-10-21
  • Int'l Joint Research
• [Presentation] “Effect of FXR agonist Nelumal A on colitis and colorectal carcinogenesis in mice.” (2015)
  • Author(s): Tsuneyuki Miyazaki, Noritaka Ozawa, Takahiro Kochi, Naoki Watanabe, Hiroyasu Sakai, Yohei Shirakami, Takuji Tanaka, Masahito Shimizu, Hisataka Moriwaki
  • Organizer: The 3rd International Conference on Retinoids
  • Place of Presentation: 岐阜
  • Year and Date: 2015-10-21
  • Int'l Joint Research
• [Presentation] 大腸発癌モデルにおける選択的EP4受容体拮抗薬RQ-00015986の作用 (2015)
  • Author(s): 白上洋平、出田貴康、宮崎恒起、河内隆宏、境 浩康、清水雅仁、清島 満
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-10
• [Presentation] 新規芳香族変異源物質5-amino-6-hydroxy-8H-benzo[6,7]azepino[5,4,3-de]quinolin-7-one (ABAQ)の大腸発癌実験における有用性について (2015)
  • Author(s): 河内隆宏、白上洋平、清水雅仁
  • Organizer: JDDW 2015（第57回日本消化器病学会大会）
  • Place of Presentation: 東京
  • Year and Date: 2015-10-09
• [Presentation] Prevention of lifestyle disease-related gastroenterological carcinogenesis through regulation of oxidative stress. (English Session (2015)
  • Author(s): Kochi T, Shirakami Y, Shimizu M.
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-09
• [Presentation] DPP4阻害薬テネリグリプチンのNAFLDモデルマウスにおける効果 (2015)
  • Author(s): 出田貴康 白上洋平 宮崎恒起 河内隆宏 境 浩康 清水雅仁
  • Organizer: JDDW 2015（第19回日本肝臓学会大会）
  • Place of Presentation: 東京
  • Year and Date: 2015-10-08
• [Presentation] The role of the phosphorylated RXR-alpha on diethylnitrosamine-induced liver tumorigenesis in mice. (2015)
  • Author(s): Sakai H, Yamada Y, Shirakami Y, Hara A, and Shimizu M.
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] 非環式レチノイドによる抗HBV作用 (2015)
  • Author(s): 白上洋平 清水雅仁
  • Organizer: 日本医療研究開発機構（肝炎等克服実用化研究事業）合同班会議
  • Place of Presentation: 東京
  • Year and Date: 2015-07-11
• [Presentation] ラット大腸発癌モデルにおけるペントキシフィリンの発癌抑制効果 (2015)
  • Author(s): 白上洋平、出田貴康、宮崎恒起、河内隆宏、境 浩康、清水雅仁、清島 満
  • Organizer: がん予防学術大会2015（第22回日本がん予防学会総会）
  • Place of Presentation: 埼玉
  • Year and Date: 2015-06-06
• [Presentation] 肥満関連肝発癌におけるアスタキサンチンの抑制効果 (2015)
  • Author(s): 出田貴康、大野智彦、宮崎恒起、河内隆宏、白上洋平、清水雅仁
  • Organizer: がん予防学術大会2015（第22回日本がん予防学会総会）
  • Place of Presentation: 埼玉
  • Year and Date: 2015-06-06
• [Presentation] NAFLDモデルマウスにおけるDPP4阻害薬テネリグリプチンの影響 (2015)
  • Author(s): 出田貴康、白上洋平、宮崎恒起、河内隆宏、境 浩康、清水雅仁
  • Organizer: 第51回日本肝臓学会総会
  • Place of Presentation: 熊本
  • Year and Date: 2015-05-21
• [Presentation] NAFLD/NASHモデルマウスにおいてDPP4阻害薬テネリグリプチンは肝脂肪化を抑制する (2015)
  • Author(s): 出田貴康、白上洋平、宮崎恒起、河内隆宏、境 浩康、清水雅仁
  • Organizer: 第101回日本消化器病学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2015-04-25
• [Presentation] アスタキサンチンによる肥満関連肝・大腸発癌の抑制効果 (2015)
  • Author(s): 河内隆宏、白上洋平、出田貴康、宮崎恒起、清水雅仁
  • Organizer: 第101回日本消化器病学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2015-04-24
• [Presentation] ラット大腸発癌モデルにおける選択的EP4受容体拮抗薬の作用 (2015)
  • Author(s): 白上洋平、中西孝之、河内隆宏、出田貴康、宮崎恒起、清水雅仁、清島 満
  • Organizer: 第101回日本消化器病学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2015-04-24
• [Presentation] 酸化ストレスの制御を介した生活習慣病関連消化器発癌の抑制 (2015)
  • Author(s): 清水雅仁 河内隆宏 白上洋平
  • Organizer: 第101回日本消化器病学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2015-04-23
• [Presentation] Preventive effect of a prostaglandin E receptor EP4 antagonist on rat colon tumorigenesis. (2015)
  • Author(s): Shirakami Y, Sakai H, Kochi T, Ideta T, Miyazaki T, Shimizu M, Seishima M.
  • Organizer: 106th American Association for Cancer Research (AACR) Annual Meeting
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2015-04-21
  • Int'l Joint Research
• [Presentation] Preventive effects of branched-chain amino acid supplementation on the spontaneous development of hepatic preneoplastic lesions in C57BL/KsJ-db/db obese mice. (2015)
  • Author(s): Ideta T, Terakura D, Shimizu M, Miyazaki T, Kochi T, Sakai H, Shirakami Y, Tanaka T, Moriwaki H.
  • Organizer: 106th American Association for Cancer Research (AACR) Annual Meeting
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2015-04-21
  • Int'l Joint Research
• [Presentation] The role of the phosphorylated RXR-alpha on cellular proliferation and liver tumorigenesis. (2015)
  • Author(s): Sakai H, Shirakami Y, Shimizu M, and Moriwaki H.
  • Organizer: 106th American Association for Cancer Research (AACR) Annual Meeting
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2015-04-20
  • Int'l Joint Research
• [Presentation] 大腸発癌モデルにおけるペントキシフィリンの発癌抑制効果 (2014)
  • Author(s): 白上洋平 清水雅仁 河内隆宏 森脇久隆 清島 満
  • Organizer: JDDW2014（第56回日本消化器病学会大会）
  • Place of Presentation: 神戸
  • Year and Date: 2014-10-23
• [Presentation] B型肝炎ウイルスに対する非環式レチノイドの効果 (2014)
  • Author(s): 白上洋平 出田貴康 宮崎恒起 境 浩康 清水雅仁
  • Organizer: 日本レチノイド研究会第25回学術集会
  • Place of Presentation: 秋田
  • Year and Date: 2014-10-12
• [Presentation] アスタキサンチンによる肥満関連発癌の抑制効果 (2014)
  • Author(s): 出田貴康 大野智彦 宮崎恒起 河内隆宏 境 浩康 白上洋平 清水雅仁 森脇久隆
  • Organizer: 日本レチノイド研究会第25回学術集会
  • Place of Presentation: 秋田
  • Year and Date: 2014-10-12
• [Presentation] Wip1 prevents cellular senescence at physiological oxygen levels by regulating DNA damage response (DDR) during S-phase. (2014)
  • Author(s): Sakai H, Shirakami Y, Shimizu M, Moriwaki H.
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-27
• [Presentation] Targeting obesity-related metabolic abnormalities for chemoprevention of hepatocellular carcinoma. (2014)
  • Author(s): Shimizu M, Shirakami Y, Sakai H, Kubota M, Kochi T, Tanaka T, Moriwaki H.
  • Organizer: 97.第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-26
• [Presentation] Chemopreventive effects of pentoxifylline on inflammation-related rat colon tumorigenesis and endoscopic observation. (2014)
  • Author(s): Shirakami Y, Shimizu M, Kochi T, Moriwaki H, Seishima M.
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-26
• [Presentation] Effects of histamine receptor antagonists on inflammation-associated colon carcinogenesis in mice. (2014)
  • Author(s): Tanaka T, Kochi T, Shirakami Y, Watanabe N, Moriwaki H, Shimizu M.
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-26
• [Presentation] Sodium alginate prevents the progression of non-alcoholic steatohepatitis and liver carcinogenesis in mice. (2014)
  • Author(s): Miyazaki T, Kubota M, Kochi T, Shirakami Y, Shimizu M, Tanaka T, Moriwaki H.
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-25
• [Presentation] A novel mouse model of NASH-related liver cancer and preventive effects of pentoxifylline on liver tumorigenesis. (2014)
  • Author(s): Shirakami Y, Shimizu M, Sakai H, Moriwaki H, Seishima M.
  • Organizer: The 12th Japan-Korea Joint Symposium on Cancer and Ageing Research
  • Place of Presentation: 埼玉
  • Year and Date: 2014-06-21
• [Presentation] Wild-type p53-inducible phosphatase 1 (Wip1) forestalls cellular senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication. (2014)
  • Author(s): Sakai H, Shirakami Y, Shimizu M, Moriwaki H.
  • Organizer: The 12th Japan-Korea Joint Symposium on Cancer and Ageing Research
  • Place of Presentation: 埼玉
  • Year and Date: 2014-06-21
• [Presentation] Impact of hypertension on colorectal carcinogenesis and prevention of colonic preneoplastic lesions by captopril. (2014)
  • Author(s): Miyazaki T, Kochi T, Shimizu M, Ohno T, Baba A, Sumi T, Kubota M, Shirakami Y, Tsurumi H, Tanaka T, Moriwaki H.
  • Organizer: The 12th Japan-Korea Joint Symposium on Cancer and Ageing Research
  • Place of Presentation: 埼玉
  • Year and Date: 2014-06-21
• [Presentation] Preventive effects of branched-chain amino acid supplementation on the spontaneous development of hepatic preneoplastic lesions in C57BL/KsJ-db/db obese mice. (2014)
  • Author(s): Ideta T, Terakura D, Masahito S, Miyazaki T, Iwasa J, Baba A, Kochi T, Ohno T, Kubota M, Sakai H, Shirakami Y, Shiraki M, Takai K, Turumi H, Tanaka T, Moriwaki H.
  • Organizer: The 12th Japan-Korea Joint Symposium on Cancer and Ageing Research
  • Place of Presentation: 埼玉
  • Year and Date: 2014-06-20
• [Presentation] A synthetic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic db/db mice. (2014)
  • Author(s): Shirakami Y, Shimizu M, Sakai H, Moriwaki H.
  • Organizer: The 2nd International Conference on Retinoids (FASEB Meeting 2014)
  • Place of Presentation: Itasca, Illinois, USA
  • Year and Date: 2014-06-03
• [Presentation] The role of the phosphorylated RXR-alpha on cellular proliferation and liver tumorigenesis. (2014)
  • Author(s): Sakai H, Shirakami Y, Shimizu M, Moriwaki H.
  • Organizer: The 2nd International Conference on Retinoids (FASEB Meeting 2014)
  • Place of Presentation: Itasca, Illinois, USA
  • Year and Date: 2014-06-02
• [Presentation] 肥満関連および炎症性大腸発癌モデルにおけるペントキシフィリンの発癌抑制作用 (2014)
  • Author(s): 白上洋平，清水雅仁，森脇久隆，清島 満
  • Organizer: 第100回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-25
• [Book] 臨床検査ガイド2015年改訂版 (2015)
  • Author(s): 白上洋平，清水雅仁．
  • Total Pages: 1154
  • Publisher: 文光堂
• [Book] 臨床検査ガイド 2015年改訂版 (2015)
  • Author(s): 白上洋平，清水雅仁．
  • Total Pages: 1176
  • Publisher: 文光堂