Endoscopic Molecular Imaging of Barrett's carcinoma

• Project/Area Number: 26860508
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: The University of Tokushima
• Principal Investigator: KITAMURA Shinji 徳島大学, 大学院医歯薬学研究部, 助教 (60564490)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: Barrett腺癌 / 分子イメージング

Outline of Final Research Achievements

We aim to make an endoscopic diagnosis system of Barrett's carcinomas or precancerous lesions by using a molecular Imaging in this study.
Cases of Barrett's carcinomas are limited, so we carried out basic research using the colon cancer cells, which are relatively easy to collect,at first. The EGFR is exposed high frequency in colon cancer, we dicided to use the EGFR for the target of molecular imaging. We have established the method of EGFR molecular imaging of colonic cancer.We apply same method for Barrett's carcinoma. However, EGFR expression is not necessarily high in Barrett's carcinoma, imaging in the EGFR has been difficult. The new molecular target of Barrett's carcinoma is required, we are advances the current continue to study.

Research Products

• [Presentation] Endoscopic Molecular Imaging of Colorectal Cancer Targeting Epidermal Growth Factor Receptor. (2015)
  • Author(s): Naoki Muguruma, Yoshihiko Miyamoto, Shota Fujimoto, Tadahiko Nakagawa, Shinji Kitamura, Tetsuo Kimura, Koichi Okamoto, Hiroshi Miyamoto, Kazuki Horikawa, Tetsuji Takayama.
  • Organizer: Asian Pacific Digestive Week 2015
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-12-04
  • Int'l Joint Research
• [Presentation] 大腸癌におけるEpidermal Growth Factor Receptor(EFGR)をターゲットとした分子イメージングと薬効評価, (2014)
  • Author(s): 宮本 佳彦, 六車 直樹, 北村 晋志
  • Organizer: 第88回日本消化器内視鏡学会総会
  • Place of Presentation: 神戸国際展示場（兵庫県神戸市）
  • Year and Date: 2014-10-26
• [Presentation] Optical Molecular Imaging and Assessment of Therapeutic Response of Colorectal Cancer Targeting Epidermal Growth Factor Receptor (2014)
  • Author(s): Naoki Muguruma, Miyamoto Yoshihiko, Fujimoto Shota, Okada Yasuyuki, Shinji Kitamura, Tetsuo Kimura, Koichi Okamoto, Hiroshi Miyamoto and Tetsuji Takayama
  • Organizer: World Congress of Molecular Imaging 2014
  • Place of Presentation: Seoul，South Korea
  • Year and Date: 2014-09-17
• [Presentation] バレット食道癌における欧米と日本のマネジメントの相違に関する検討 (2014)
  • Author(s): 北村 晋志, 六車 直樹, 松本 友里, 松本 早代, 岡崎 潤, 髙岡 遠, 香川 美和子, 藤野 泰輝, 三好 人正, 中村 文香, 田中 久美子, 宮本 弘志, 岡久 稔也, 高山 哲治
  • Organizer: 第87回日本消化器内視鏡学会総会
  • Place of Presentation: マリンメッセ福岡（福岡県福岡市）
  • Year and Date: 2014-05-15
• [Presentation] 大腸癌に対する内視鏡分子イメージング技術の開発 (2014)
  • Author(s): 宮本 佳彦, 六車 直樹, 北村 晋志
  • Organizer: 第87回日本消化器内視鏡学会総会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2014-05-15