| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We analyzed expression of miRNA in the hepatocellular carcinoma cell line cyclopedically, and clusters analyzed expression profiles after making and specifically identified miRNA s which caused expression changes in various kinds of hepatocellular carcinoma cell line.
Using the peripheral blood of patients with hepatocellular carcinoma given the radical operation of the hepatocellular carcinoma, we examined changes of miRNAs in the before and after therapy. The quantity of miRNA showed clear changes in before and after therapy and formed a different cluster. We significantly paid attention to miR-125a-5p as a candidate of a new tumor marker among 7 seen molecules of the decrease after treatment. It became clear that miR-125a-5p assumed molecules about cancer suppression such as the that strike of the cell cycle and the instruction of the apoptosis a target gene.
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