Role of PARVB gene in NASH

• Project/Area Number: 26860516
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Yokohama City University
• Principal Investigator: MAWATARI Norihiro 横浜市立大学, 附属病院, 助教 (00600206)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 脂肪肝 / NASH / NAFLD / ＮＡＳＨ / 遺伝子多型 / 非アルコール性脂肪肝炎

Outline of Final Research Achievements

We investigated the genes associated to the onset and progression of Non Alcoholic Steato-Hepatitis(NASH), and identified PARVB gene is strongly associated to NASH. We further clarify the role of this gene and finally showed that this gene plays an important role for the development of chirossis.

Research Products

• [Journal Article] Resveratrol ameliorates fibrosis and inflammation in a mouse model of nonalcoholic steatohepatitis. (2016)
  • Author(s): Kessoku T, Imajo K, Honda Y, et al.
  • Journal Title: Sci Rep Volume: 25 Issue: 1 Pages: 22251-22251
  • DOI: 10.1038/srep22251
  • NAID: 120005749754
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The characteristics of non-obese NAFLD: Effect of genetic and environmental factors. (2016)
  • Author(s): Honda Y, Yoneda M, Kessoku T, Ogawa Y, Tomeno W, Imajo K, Mawatari H, Fujita K, Hyogo H, Ueno T, Chayama K, Saito S, Nakajima A, Hotta K
  • Journal Title: Hepatol Res Volume: - Issue: 10 Pages: 636-636
  • DOI: 10.1111/hepr.12648
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Magnetic Resonance Imaging More Accurately Classifies Steatosis and Fibrosis in Nonalcoholic Fatty Liver Disease Than Transient Elastography. (2016)
  • Author(s): Imajo K, Kessoku T, Honda Y, Tomeno W, Ogawa Y, Mawatari H, Fujita K, Yoneda M, Taguri M, Hyogo H, Sumida Y, Ono M, Eguchi Y, Inoue T,Yamanaka T, Wada K, Saito S, Nakajima A
  • Journal Title: Gastroenterology Volume: 150 Issue: 3 Pages: 626-37
  • DOI: 10.1053/j.gastro.2015.11.048
  • Peer Reviewed / Open Access / Int'l Joint Research