Role of PARVB gene in NASH
Project/Area Number |
26860516
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
|
Research Institution | Yokohama City University |
Principal Investigator |
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 脂肪肝 / NASH / NAFLD / NASH / 遺伝子多型 / 非アルコール性脂肪肝炎 |
Outline of Final Research Achievements |
We investigated the genes associated to the onset and progression of Non Alcoholic Steato-Hepatitis(NASH), and identified PARVB gene is strongly associated to NASH. We further clarify the role of this gene and finally showed that this gene plays an important role for the development of chirossis.
|
Report
(3 results)
Research Products
(3 results)
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[Journal Article] Resveratrol ameliorates fibrosis and inflammation in a mouse model of nonalcoholic steatohepatitis2016
Author(s)
Kessoku T, Imajo K, Honda Y, Kato T, Ogawa Y, Tomeno W, Kato S, Mawatari H, Fujita K, Yoneda M, Nagashima Y, Saito S, Wada K, Nakajima A
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Journal Title
Sci Rep
Volume: 6
Pages: 22251
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The characteristics of non-obese NAFLD: Effect of genetic and environmental factors2016
Author(s)
Honda Y, Yoneda M, Kessoku T, Ogawa Y, Tomeno W, Imajo K, Mawatari H, Fujita K, Hyogo H, Ueno T, Chayama K, Saito S, Nakajima A, Hotta K
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Journal Title
Hepatol Res
Volume: [Epub ahead of print]
Pages: 636
DOI
Related Report
Peer Reviewed
-
[Journal Article] Magnetic Resonance Imaging More Accurately Classifies Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease Than Transient Elastography2016
Author(s)
Imajo K, Kessoku T, Honda Y, Tomeno W, Ogawa Y, Mawatari H, Fujita K, Yoneda M, Taguri M, Hyogo H, Sumida Y, Ono M, Eguchi Y, Inoue T, Yamanaka T, Wada K, Saito S, Nakajima A
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Journal Title
Gastroenterology
Volume: 150
Pages: 626-637
DOI
Related Report
Peer Reviewed / Open Access