The mechanism of new photodynamic therapy targeting cancer stem cell with glycoconjugated chlorin

• Project/Area Number: 26860520
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Nagoya City University
• Principal Investigator: TANAKA Mamoru 名古屋市立大学, 大学院医学研究科, 研究員 (80617861)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: Photodynamic therapy / Cancert Stem Cell / c-Myc / Glut1 / PDT / がん幹細胞 / HIF1 / p53 / HIF1α

Outline of Final Research Achievements

Photodynamic therapy (PDT) consists of the administration of a photosensitizer together with visible light irradiation at a specific wavelength to activate the photosensitizer, leading to the conversion of molecular oxygen to various highly reactive oxygen species (ROS), which either kill tumor cells directly or damage the tumor- associated vasculature. G-chlorin (glycoconjugated chlorin; glucose-linked tetra (fluorophenyl) chlorin) has been developed as a new type of photosensitizer. In the current study, we show that PDT with a new photosensitizer, G-chlorin

Research Products

• [Journal Article] Immunogenic cell death due to a new photodynamic therapy with glycoconjugated chlorin (2016)
  • Author(s): Tanaka M, Kataoka H, Yano S, Sawada T, Akashi H, Inoue M, Suzuki S, Inagaki Y, Hayashi N, Nishie H, Shimura T, Mizoshita T, Mori Y, Kubota E, Tanida S, Takahashi S, Joh T.
  • Journal Title: Oncotarget Volume: 26; 7(30) Issue: 30 Pages: 47242-47251
  • DOI: 10.18632/oncotarget.9725
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 糖鎖連結クロリンを用いた新規光線力学的がん診断法 (2014)
  • Author(s): ○Mamoru Tanaka, Hiromi Kataoka, Shingo Hamano, Masahide Ebi, Tsutomu Mizoshita, Yoshinori Mori, Eiji Kubota, Shigenobu Yano and Takashi Joh
  • Organizer: 第72回日本癌学会 学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Novel photodynamic therapy with glucose conjugated chlorin for GIST (2014)
  • Author(s): Mamoru Tanaka, Hiromi Kataoka, Noriyuki Hayashi, Shigenobu Yano and Takashi Joh
  • Organizer: 23th EACR European Association for Cancer Research
  • Place of Presentation: ベルリン（ドイツ）
  • Year and Date: 2014-07-05 – 2014-07-08