Study on miRNA expression and single nucleotide polymorphisms in hepatocellular carcinoma after HCV eradication
| Project/Area Number |
26860522
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka City University |
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Principal Investigator |
HOANG HAI 大阪市立大学, 大学院医学研究科, 研究員 (60623246)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWADA Norifumi 大阪市立大学, 大学院医学研究科, 教授 (30271191)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | HCC SNP / 遺伝子 |
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| Outline of Final Research Achievements |
Of the 4 SNPs analysed, only the MICA genotypes were significantly associated with development of HCC (p = 0.0185). The major (MA), hetero (HE), and minor (MI) genotypes occurred in 40%, 41%, and 19% of HCC patients and in 43%, 47%, and 10% of non-HCC patients, respectively. Interestingly, the MICA genotype was significantly correlated with soluble MICA protein levels. In patients older than 70 years, the MI genotype was significantly associated with HCC development. In addition, the MI genotype was related to HCC development when the platelet count range was 10-15 × 104/μL but not when the range was less than 10 or greater than 15 × 104/μL. Thus, polymorphisms in MICA, but not in DEPDC5, HCP5 or PNPLA3, are associated with HCC development in Japanese patients with chronic HCV infection, particularly older patients or patients with fibrosis.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] 4.Randomized trial of combined triple therapy comprising two types of peginterferon with simeprevir in patients with HCV genotype 1b2016
Author(s)
Tamori A, Yoshida K, Kurai O, Kioka K, Hai H, Kozuka R, Motoyama H, Kawamura E, Hagihara A, Uchida-Kobayashi S, Morikawa H, Enomoto M, Murakami Y, Kawada N
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Journal Title
Hepatol Res.
Volume: 46
Issue: 8
Pages: 1311-1320
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway.2015
Author(s)
Thuy Le TT, Matsumoto Y, Thuy TT, Hai H, Suoh M, Urahara Y, Motoyama H, Fujii,Tamori A, Kubo S, Takemura S, Morita T, Yoshizato K, Kawada N.
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Journal Title
Am J Pathol.
Volume: 185
Pages: 1045-1060
Related Report
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[Journal Article] Effects on anemia of drug adjustment in patients with chronic hepatitis C during teleaprevir-combined therapy.2015
Author(s)
Tamori A, Kioka K, Sakaguchi H, Enommoto M, Hai H, Kawamura E, Hagihara A, Fujii H, Uchida-Kobayashi S, Iwai S, Morikawa H, Murakami Y, Kawadaki Y, Tsuruta D, Kawada N.
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Journal Title
Ann Hepatol.
Volume: 14
Pages: 28-35
Related Report
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[Presentation] Changes in NS3/4A and NS5A resistance-associated variants of hepatitis C virus after treatment failure with direct-acting antiviral(s)2016
Author(s)
Hai H, Yoshida K, Tamori A, Enomoto M, Morikawa H, Kozuka R, Teranishi Y, Motoyama H, Kawamura E, Hagihara A, Murakami Y, Thuy LTT, Kawada N
Organizer
AASLD 2016 Annual Meeting
Place of Presentation
Boston, MA, USA
Year and Date
2016-11-11
Related Report
Int'l Joint Research / Invited
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[Presentation] MICA SNP, but not DEPDC5, PNPLA3 and HCP5 SNPs, is associated with chronic hepatitis C-related hepatocellular carcinoma2015
Author(s)
Hoang Hai, Akihiro Tamori, Kanako Yoshida, Atsushi Hagihara, Etsushi Kawamura, Sawako K. Uchida, Hiroyasu Morikawa, Masaru Enomoto, Yoshiki Murakami, Thuy T. Le, Norifumi Kawada.
Organizer
AASLD Annual Meeting.
Place of Presentation
サンフランシスコ(アメリカ合衆国)
Year and Date
2015-11-13
Related Report
Int'l Joint Research
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