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Interaction of miR-221/222 and adipocytokine signaling in esophageal adenocarcinoma

Research Project

Project/Area Number 26860527
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionKeio University

Principal Investigator

Matsuzaki Juntaro  慶應義塾大学, 医学部, 講師(非常勤) (60464864)

Research Collaborator TSUGAWA Hitoshi  
SUZUKI Hidekazu  
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords食道腺がん / 中心性肥満 / アディポネクチン / マイクロRNA / 胆汁酸 / 内臓脂肪 / 肥満
Outline of Final Research Achievements

Esophageal adenocarcinoma, which is rapidly increasing in Western countries, is one of the complications of gastroesophageal reflux disease. Bile reflux and central obesity are major risk factors for esophageal adenocarcinoma. In general, plasma adiponectin levels are decreased through the progression of central obesity. We had reported that bile acids contribute to carcinogenesis through the activation of nuclear bile acid receptor (FXR) and the enhancement of miR-221/222. Herein, we identified that miR-221/222 enhance the expression of COX-2 in esophageal epithelial cells. On the other hand, COX-2 expression was suppressed during exposure to adiponectin receptor agonist. These results suggest adiponectin receptor agonist might work as a chemopreventive agent for esophageal adenocarcinoma among high-risk individuals with central obesity.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (15 results)

All 2016 2015 2014

All Journal Article (10 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 10 results,  Open Access: 10 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Association of baseline plasma des-acyl ghrelin level with the response to rikkunshito in patients with functional dyspepsia.2016

    • Author(s)
      Togawa, K., Matsuzaki, J., Kobayakawa, M., Fukushima, Y., Suzaki, F., Kasugai, K., Nishizawa, T., Naito, Y., Hayakawa, T., Kamiya, T., Andoh, T., Yoshida, H., Tokura, Y., Nagata, H., Mori, M., Kato, K., Hosoda, H., Takebayashi, T., Miura, S., Uemura, N., Joh, T., Hibi, T., Suzuki, H.
    • Journal Title

      J. Gastroenterol. Hepatol.

      Volume: 31 Issue: 2 Pages: 334-341

    • DOI

      10.1111/jgh.13074

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel combination of serum microRNA for detecting breast cancer in the early stage2016

    • Author(s)
      Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Kenji T, Ochiya T
    • Journal Title

      Cancer Sci

      Volume: 107 Issue: 3 Pages: 326-334

    • DOI

      10.1111/cas.12880

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of Visceral Fat Area, Smoking, and Alcohol Consumption with Reflux Esophagitis and Barrett's Esophagus in Japan.2015

    • Author(s)
      Matsuzaki J, Suzuki H, Kobayakawa M, Inadomi JM, Takayama M, Makino K, Iwao Y, Sugino Y, Kanai T
    • Journal Title

      PLoS One.

      Volume: 10 Issue: 7 Pages: 1-15

    • DOI

      10.1371/journal.pone.0133865

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of microRNAs-221/222 in digestive systems.2015

    • Author(s)
      Matsuzaki, J., Suzuki, H.
    • Journal Title

      J. Clin. Med.

      Volume: 4 Issue: 8 Pages: 1566-1577

    • DOI

      10.3390/jcm4081566

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Safety and benefits of self-expandable metallic stents with chemotherapy for malignant gastric outlet obstruction.2015

    • Author(s)
      Miyabe K, Hayashi K, Nakazawa T, Sano H, Yamada T, Takada H, Naitoh I, Shimizu S, Kondo H, Nishi Y, Yoshida M, Umemura S, Hori Y, Kato A, Ohara H, Joh T.
    • Journal Title

      Digestive Endoscopy

      Volume: 27 Issue: 1 Pages: 572-81

    • DOI

      10.1159/000440741

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Musosal expression of aquaporin-4 in the stomach of histamine type 2 receptor knockout mice and Helicobacter pylori-infected mice.2014

    • Author(s)
      Fukuhara, S., Matsuzaki, J., Tsugawa, H., Masaoka, T., Miyoshi, S., Mori, H., Fukushima, Y., Yasui, M., Kanai, T., Suzuki, H.
    • Journal Title

      J. Gastroenterol. Hepatol.

      Volume: 29 Issue: S4 Pages: 53-59

    • DOI

      10.1111/jgh.12771

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Greater loss of productivity among Japanese workers with gastroesophageal reflux disease (GERD) symptoms that persist vs resolve on medical therapy.2014

    • Author(s)
      Suzuki, H., Matsuzaki, J., Masaoka, T., Inadomi, J.M.
    • Journal Title

      Neurogastroenterol. Motil.

      Volume: - Issue: 6 Pages: 764-771

    • DOI

      10.1111/nmo.12319

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] MicroRNAs in Barrett’s esophagus: Future prospects.2014

    • Author(s)
      Matsuzaki, J., Suzuki, H.
    • Journal Title

      Front. Genet.

      Volume: 5 Pages: 69-69

    • DOI

      10.3389/fgene.2014.00069

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Randomised clinical trial : rikkunshito in the treatment of functional dyspepsia–a multi-centre, double-blind, randomised, placebo-controlled study2014

    • Author(s)
      Suzuki, H., Matsuzaki, J., Fukushima, Y., Suzaki, F., Kasugai, K., Nishizawa, T., Naito, Y., Hayakawa, T., Kamiya, T., Andoh, T., Yoshida, H., Tokura, Y., Nagata, H., Kobayakawa, M., Mori, M., Kato, K., Hosoda, H., Takabayashi, T., Miura, S., Uemura, N., Joh, T., Hibi, T., Tack, J.
    • Journal Title

      Neurogastr oenterol. Motil.

      Volume: (Epub) Issue: 7 Pages: 950-961

    • DOI

      10.1111/nmo.12348

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Propofol vs traditional sedative agents for endoscopic submucosal dissection: A systematic review.2014

    • Author(s)
      Nishizawa, T., Suzuki, H., Matsuzaki, J., Kanai, T., Yahagi, N.
    • Journal Title

      Digest. Endosc.

      Volume: 26 Issue: 6 Pages: 701-706

    • DOI

      10.1111/den.12342

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Adiponectin ameliorates carcinogenic pathway depending on miR-221/222 in esophageal adenocarcinoma cells2015

    • Author(s)
      Juntaro Matsuzaki
    • Organizer
      Digestive Disease Week 2015
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2015-05-19
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 胆汁酸曝露による食道腺がん進展機序に対するアディポネクチンの抗腫瘍効果の検討2015

    • Author(s)
      松崎 潤太郎
    • Organizer
      第101回日本消化器病学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Metronidazole-resistant H. pylori is more prevalent in patients with dyspepsia2015

    • Author(s)
      Juntaro Matsuzaki
    • Organizer
      Asian Neurogastroenterology and Motility Association (ANMA) 2015
    • Place of Presentation
      インド, デリー
    • Year and Date
      2015-02-08
    • Related Report
      2014 Research-status Report
  • [Presentation] 食道への胆汁酸曝露によるmiR-221/222亢進を介した食道腺がん進展機序におけるアディポネクチンの関与2014

    • Author(s)
      松崎潤太郎
    • Organizer
      JDDW 2014
    • Place of Presentation
      神戸
    • Year and Date
      2014-10-24
    • Related Report
      2014 Research-status Report
  • [Presentation] Adiponectin ameliorates FXR-dependent oncogenic signaling in esophageal adenocarcinoma cells2014

    • Author(s)
      Juntaro Matsuzaki
    • Organizer
      Falk Symposium 194
    • Place of Presentation
      ドイツ, フライブルク
    • Year and Date
      2014-10-08 – 2014-10-09
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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