Interaction of miR-221/222 and adipocytokine signaling in esophageal adenocarcinoma

• Project/Area Number: 26860527
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Keio University
• Principal Investigator: Matsuzaki Juntaro 慶應義塾大学, 医学部, 講師(非常勤) (60464864)
• Research Collaborator: TSUGAWA Hitoshi ; SUZUKI Hidekazu
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 食道腺がん / 中心性肥満 / アディポネクチン / マイクロRNA / 胆汁酸 / 内臓脂肪 / 肥満

Outline of Final Research Achievements

Esophageal adenocarcinoma, which is rapidly increasing in Western countries, is one of the complications of gastroesophageal reflux disease. Bile reflux and central obesity are major risk factors for esophageal adenocarcinoma. In general, plasma adiponectin levels are decreased through the progression of central obesity. We had reported that bile acids contribute to carcinogenesis through the activation of nuclear bile acid receptor (FXR) and the enhancement of miR-221/222. Herein, we identified that miR-221/222 enhance the expression of COX-2 in esophageal epithelial cells. On the other hand, COX-2 expression was suppressed during exposure to adiponectin receptor agonist. These results suggest adiponectin receptor agonist might work as a chemopreventive agent for esophageal adenocarcinoma among high-risk individuals with central obesity.

Research Products

• [Journal Article] Association of baseline plasma des-acyl ghrelin level with the response to rikkunshito in patients with functional dyspepsia. (2016)
  • Author(s): Togawa, K., Matsuzaki, J., Kobayakawa, M., Fukushima, Y., Suzaki, F., Kasugai, K., Nishizawa, T., Naito, Y., Hayakawa, T., Kamiya, T., Andoh, T., Yoshida, H., Tokura, Y., Nagata, H., Mori, M., Kato, K., Hosoda, H., Takebayashi, T., Miura, S., Uemura, N., Joh, T., Hibi, T., Suzuki, H.
  • Journal Title: J. Gastroenterol. Hepatol. Volume: 31 Issue: 2 Pages: 334-341
  • DOI: 10.1111/jgh.13074
  • Peer Reviewed / Open Access
• [Journal Article] Novel combination of serum microRNA for detecting breast cancer in the early stage (2016)
  • Author(s): Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Kenji T, Ochiya T
  • Journal Title: Cancer Sci Volume: 107 Issue: 3 Pages: 326-334
  • DOI: 10.1111/cas.12880
  • Peer Reviewed / Open Access
• [Journal Article] Association of Visceral Fat Area, Smoking, and Alcohol Consumption with Reflux Esophagitis and Barrett's Esophagus in Japan. (2015)
  • Author(s): Matsuzaki J, Suzuki H, Kobayakawa M, Inadomi JM, Takayama M, Makino K, Iwao Y, Sugino Y, Kanai T
  • Journal Title: PLoS One. Volume: 10 Issue: 7 Pages: 1-15
  • DOI: 10.1371/journal.pone.0133865
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Role of microRNAs-221/222 in digestive systems. (2015)
  • Author(s): Matsuzaki, J., Suzuki, H.
  • Journal Title: J. Clin. Med. Volume: 4 Issue: 8 Pages: 1566-1577
  • DOI: 10.3390/jcm4081566
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Safety and benefits of self-expandable metallic stents with chemotherapy for malignant gastric outlet obstruction. (2015)
  • Author(s): Miyabe K, Hayashi K, Nakazawa T, Sano H, Yamada T, Takada H, Naitoh I, Shimizu S, Kondo H, Nishi Y, Yoshida M, Umemura S, Hori Y, Kato A, Ohara H, Joh T.
  • Journal Title: Digestive Endoscopy Volume: 27 Issue: 1 Pages: 572-81
  • DOI: 10.1159/000440741
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Musosal expression of aquaporin-4 in the stomach of histamine type 2 receptor knockout mice and Helicobacter pylori-infected mice. (2014)
  • Author(s): Fukuhara, S., Matsuzaki, J., Tsugawa, H., Masaoka, T., Miyoshi, S., Mori, H., Fukushima, Y., Yasui, M., Kanai, T., Suzuki, H.
  • Journal Title: J. Gastroenterol. Hepatol. Volume: 29 Issue: S4 Pages: 53-59
  • DOI: 10.1111/jgh.12771
  • Peer Reviewed / Open Access
• [Journal Article] Greater loss of productivity among Japanese workers with gastroesophageal reflux disease (GERD) symptoms that persist vs resolve on medical therapy. (2014)
  • Author(s): Suzuki, H., Matsuzaki, J., Masaoka, T., Inadomi, J.M.
  • Journal Title: Neurogastroenterol. Motil. Volume: - Issue: 6 Pages: 764-771
  • DOI: 10.1111/nmo.12319
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNAs in Barrett’s esophagus: Future prospects. (2014)
  • Author(s): Matsuzaki, J., Suzuki, H.
  • Journal Title: Front. Genet. Volume: 5 Pages: 69-69
  • DOI: 10.3389/fgene.2014.00069
  • Peer Reviewed / Open Access
• [Journal Article] Randomised clinical trial : rikkunshito in the treatment of functional dyspepsia–a multi-centre, double-blind, randomised, placebo-controlled study (2014)
  • Author(s): Suzuki, H., Matsuzaki, J., Fukushima, Y., Suzaki, F., Kasugai, K., Nishizawa, T., Naito, Y., Hayakawa, T., Kamiya, T., Andoh, T., Yoshida, H., Tokura, Y., Nagata, H., Kobayakawa, M., Mori, M., Kato, K., Hosoda, H., Takabayashi, T., Miura, S., Uemura, N., Joh, T., Hibi, T., Tack, J.
  • Journal Title: Neurogastr oenterol. Motil. Volume: (Epub) Issue: 7 Pages: 950-961
  • DOI: 10.1111/nmo.12348
  • Peer Reviewed / Open Access
• [Journal Article] Propofol vs traditional sedative agents for endoscopic submucosal dissection: A systematic review. (2014)
  • Author(s): Nishizawa, T., Suzuki, H., Matsuzaki, J., Kanai, T., Yahagi, N.
  • Journal Title: Digest. Endosc. Volume: 26 Issue: 6 Pages: 701-706
  • DOI: 10.1111/den.12342
  • Peer Reviewed / Open Access
• [Presentation] Adiponectin ameliorates carcinogenic pathway depending on miR-221/222 in esophageal adenocarcinoma cells (2015)
  • Author(s): Juntaro Matsuzaki
  • Organizer: Digestive Disease Week 2015
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2015-05-19
  • Int'l Joint Research
• [Presentation] 胆汁酸曝露による食道腺がん進展機序に対するアディポネクチンの抗腫瘍効果の検討 (2015)
  • Author(s): 松崎 潤太郎
  • Organizer: 第101回日本消化器病学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2015-04-23
• [Presentation] Metronidazole-resistant H. pylori is more prevalent in patients with dyspepsia (2015)
  • Author(s): Juntaro Matsuzaki
  • Organizer: Asian Neurogastroenterology and Motility Association (ANMA) 2015
  • Place of Presentation: インド, デリー
  • Year and Date: 2015-02-08
• [Presentation] 食道への胆汁酸曝露によるmiR-221/222亢進を介した食道腺がん進展機序におけるアディポネクチンの関与 (2014)
  • Author(s): 松崎潤太郎
  • Organizer: JDDW 2014
  • Place of Presentation: 神戸
  • Year and Date: 2014-10-24
• [Presentation] Adiponectin ameliorates FXR-dependent oncogenic signaling in esophageal adenocarcinoma cells (2014)
  • Author(s): Juntaro Matsuzaki
  • Organizer: Falk Symposium 194
  • Place of Presentation: ドイツ, フライブルク
  • Year and Date: 2014-10-08 – 2014-10-09