Interaction of miR-221/222 and adipocytokine signaling in esophageal adenocarcinoma
Project/Area Number |
26860527
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
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Research Institution | Keio University |
Principal Investigator |
|
Research Collaborator |
TSUGAWA Hitoshi
SUZUKI Hidekazu
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 食道腺がん / 中心性肥満 / アディポネクチン / マイクロRNA / 胆汁酸 / 内臓脂肪 / 肥満 |
Outline of Final Research Achievements |
Esophageal adenocarcinoma, which is rapidly increasing in Western countries, is one of the complications of gastroesophageal reflux disease. Bile reflux and central obesity are major risk factors for esophageal adenocarcinoma. In general, plasma adiponectin levels are decreased through the progression of central obesity. We had reported that bile acids contribute to carcinogenesis through the activation of nuclear bile acid receptor (FXR) and the enhancement of miR-221/222. Herein, we identified that miR-221/222 enhance the expression of COX-2 in esophageal epithelial cells. On the other hand, COX-2 expression was suppressed during exposure to adiponectin receptor agonist. These results suggest adiponectin receptor agonist might work as a chemopreventive agent for esophageal adenocarcinoma among high-risk individuals with central obesity.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Questionnaire-Based Survey on Diagnostic and Therapeutic Endoscopies and H. pylori Eradication for Elderly Patients in East Asian Countries2016
Author(s)
Matsuzaki J, Hayashi R, Arakawa T, Ueno F, Kinoshita Y, Joh T, Takahashi S, Naito Y, Fukudo S, Chan F, Hahm KB, Kachitorn U, Fock KM, Syam AF, Rani AA, Sollano JD, Zhu Q, Fujiwara Y, Kubota E, Kataoka H, Tokunaga K, Uchiyama K, Suzuki H
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Journal Title
Digestion
Volume: 93
Pages: 93-102
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Association of baseline plasma des-acyl ghrelin level with the response to rikkunshito in patients with functional dyspepsia2016
Author(s)
Togawa K, Matsuzaki J, Fukushima Y, Suzaki F, Kasugai K, Nishizawa T, Naito Y, Hayakawa T, Kamiya T, Andoh T, Yoshida H, Tokura Y, Nagata H, Kobayakawa M, Mori M, Kato K, Hosoda H, Takebayashi T, Miura S, Uemura N, Joh T, Hibi T, Suzuki H
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Journal Title
J Gastroenterol Hepatol
Volume: 31
Pages: 334-341
DOI
Related Report
Peer Reviewed
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[Journal Article] Novel combination of serum microRNA for detecting breast cancer in the early stage2016
Author(s)
Shimomura A, Shiino S, Kawauchi J, Takizawa S, Sakamoto H, Matsuzaki J, Ono M, Takeshita F, Niida S, Shimizu C, Fujiwara Y, Kinoshita T, Kenji T, Ochiya T
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Journal Title
Cancer Sci
Volume: 107
Pages: 326-334
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association of visceral fat area, smoking, and alcohol consumption with reflux esophagitis and Barrett’s esophagus in Japan2015
Author(s)
Matsuzaki J, Suzuki H, Kobayakawa M, Inadomi JM, Takayama M, Makino K, Iwao Y, Sugino Y, Kanai T
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Journal Title
PLoS One
Volume: 10
Pages: e0133865
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Randomised clinical trial: rikkunshito in the treatment of functional dyspepsia – a multi-centre, double-blind, randomised, placebo-controlled study2014
Author(s)
Suzuki H, Matsuzaki J, Fukushima Y, Suzaki F, Kasugai K, Nishizawa T, Naito Y, Hayakawa T, Kamiya T, Andoh T, Yoshida H, Tokura Y, Nagata H, Kobayakawa M, Mori M, Kato K, Hosoda H, Takebayashi T, Miura S, Uemura N, Joh T, Hibi T, Tack J
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Journal Title
Neurogastroenterol Motil
Volume: 26
Pages: 950-961
DOI
Related Report
Peer Reviewed
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