Development of minimaly invasive treatment for hepatic malignancies with IRE

• Project/Area Number: 26860530
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Tokyo Medical University
• Principal Investigator: Sugimoto Katsutoshi 東京医科大学, 医学部, 講師 (20385032)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 不可逆電気穿孔法 / 悪性肝腫瘍 / 肝局所療法 / 肝臓 / 悪性腫瘍 / IRE / ナノナイフ

Outline of Final Research Achievements

During the study period, we performed irreversible electroporation (IRE) therapy for 5 patients with 6 hepatocelullar carcinoma. It has found that we observed no serious side effet. Thus the treatment safety is preserved. In paticular, we could perform IRE for nodules next to major hepatic vesseles safely. Such nodules seem to be difficult to treat with thermal ablation represented by Radio frequency ablatioon. Thsu IRE is suited for such nodules.

Research Products

• [Journal Article] IRE for nonthermal tumor ablation in patients with HCC: initial clinical experience in Japan (2015)
  • Author(s): Katsutoshi Sugimoto
  • Journal Title: Jpn J Radiol Volume: 33 Issue: 7 Pages: 424-32
  • DOI: 10.1007/s11604-015-0442-1
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Assessment of various types of US findings after irreversible electroporation in porcine liver: comparison with radiofrequency ablation (2015)
  • Author(s): Sugimoto K, Moriyasu F, Kobayashi Y, Kasuya K, Nagakawa Y, Tsuchida A, Hara T, Iobe H, Oshiro H
  • Journal Title: J Vasc Interv Radiol Volume: 26 Issue: 2 Pages: 279-287
  • DOI: 10.1016/j.jvir.2014.11.007
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Case study to assess the safety of IRE near the heart (2015)
  • Author(s): Katsutoshi Sugimoto
  • Journal Title: Springerplus Volume: 11 Issue: 1 Pages: 74-74
  • DOI: 10.1186/s40064-015-0828-7
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of irreversible electroporation ablation zone (2014)
  • Author(s): Katsutoshi Sugimoto
  • Journal Title: Journal of Medical Ultrasonics Volume: 41 Issue: 4 Pages: 531-2
  • DOI: 10.1007/s10396-014-0547-7
  • Peer Reviewed / Open Access
• [Journal Article] A case of hepatocellular carcinoma successfully treated by irreversible electroporation (2014)
  • Author(s): 杉本 勝俊
  • Journal Title: Kanzo Volume: 55 Issue: 5 Pages: 290-292
  • DOI: 10.2957/kanzo.55.290
  • NAID: 130004897348
  • ISSN: 0451-4203, 1881-3593
  • Peer Reviewed / Open Access
• [Presentation] Multimodality imaging to assess immediate response following IRE in patients with malignant hepatic tumors (2016)
  • Author(s): Katsutoshi Sugimoto
  • Organizer: European Congress of Radiology
  • Place of Presentation: Vienna/Austria
  • Year and Date: 2016-03-02
  • Int'l Joint Research
• [Presentation] 肝癌に対するIREの有効性と安全性の評価 (2015)
  • Author(s): 杉本 勝俊
  • Organizer: 第１０１回日本消化器病学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2015-04-25
• [Presentation] Assessment of irreversible electroporation ablation zone (2015)
  • Author(s): Katsutoshi Sugimoto
  • Organizer: European Congress of Radiology
  • Place of Presentation: Vienna/Austria
  • Year and Date: 2015-03-06