• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of a novel method for therapy against inflammatory bowel disease with Endothelial Progenitor Cells as controlled-release preparation delivery system

Research Project

Project/Area Number 26860534
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionOsaka Medical College

Principal Investigator

KAKIMOTO KAZUKI  大阪医科大学, 医学部, 助教 (20589816)

Research Collaborator II Masaaki  大阪医科大学, 研究支援センター実験動物部門, 副部門長
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords炎症性腸疾患 / 脂肪由来幹細胞 / ナノ粒子 / 脂肪組織由来幹細胞 / 脂肪由来間葉系幹細胞
Outline of Final Research Achievements

Inflammatory bowel disease (IBD) involves chronic inflammation of the digestive tract, and there is currently no cure for IBD. In the present study, we examined the anti-inflammatory action of murine Endothelial Progenitor Cells (EPC) and Adipose-derived stem cell (AdSC) in mice model of IBD, and examined the enhancing effect of the anti-inflammatory action when attached nanoparticle statins to AdSC. On examining EPC aggregation in tissue, there was no aggregation observed for transvenous and intraperitoneal transplantation. However aggregation was observed for transarterial transplantation of AdSC.
On examining the colitis inhibitory effect via the transarterial pathway, we observed a little inhibition of Disease activity index (DAI), Histological damage score (HDS) and cytokine levels in the AdSC group compared with PBS group. However, DAI, HDS and cytokine levels were significantly lower in the Sim-AdSC group than in the PBS group.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2016

All Presentation (2 results)

  • [Presentation] スタチン封入PLGAナノ粒子抱合脂肪幹細胞による炎症性腸疾患モデルマウスに対する治療効果の検討2016

    • Author(s)
      柿本一城
    • Organizer
      日本消化器病学会
    • Place of Presentation
      神戸
    • Year and Date
      2016-11-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脂肪組織由来幹細胞を用いた徐放化薬剤伝達システムによる炎症性腸疾患モデルマウスに対する炎症抑制効果の検討2016

    • Author(s)
      柿本一城
    • Organizer
      日本消化器免疫学会
    • Place of Presentation
      大阪
    • Year and Date
      2016-07-14
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi