The investigation of genetic polymorphisms in viral-sensing pathway affecting development of diseases caused by hepatitis viruses.

• Project/Area Number: 26860536
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: MIKI Daiki 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 副チームリーダー (10584592)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: SNP

Outline of Final Research Achievements

There are distinct mechanisms for viral sensing in the early phase of infection with hepatitis B virus (HBV) and hepatitis C virus (HCV). The former is DNA virus and the latter is RNA virus. In this study, we investigated genetic polymorphisms in viral sensing pathway affecting development of diseases caused by hepatitis viruses. NTCP was recently identified as a hepatocyte receptor for HBV. It has been reported that the amino acid substitution S267F, which corresponds to a single nucleotide polymorphism (SNP) rs2296651, of NTCP is defective in HBV receptor function. However, we found that the SNP is rare and could not find any genetic association between the SNP and HBV persistence nor development of HBV-induced HCC in Japanese population. We also investigated polymorphism of viral RNA sensor RIG-I, and found a supportive data for the theory that RIG-I functions not only as a RNA sensor but as a DNA sensor.

Research Products

• [Journal Article] Efficacy and safety of daclatasvir plus asunaprevir therapy for chronic hepatitis C patients with renal dysfunction. (2017)
  • Author(s): Nakamura Y, Imamura M, Kawakami Y, Teraoka Y, Daijo K, Honda F, Morio K, Kobayashi T, Nakahara T, Nagaoki Y, Kawaoka T, Tsuge M, Hiramatsu A, Aikata H, Hayes CN, Miki D, Ochi H, Chayama K.
  • Journal Title: J Med Virol. Volume: 89 Issue: 4 Pages: 665-671
  • DOI: 10.1002/jmv.24679
  • Peer Reviewed
• [Journal Article] Safety and efficacy of dual therapy with daclatasvir and asunaprevir for older patients with chronic hepatitis C. (2017)
  • Author(s): Morio R, Imamura M, Kawakami Y, Morio K, Kobayashi T, Yokoyama S, Kimura Y, Nagaoki Y, Kawaoka T, Tsuge M, Hiramatsu A, Nelson Hayes C, Aikata H, Takahashi S, Miki D, Ochi H, Mori N, Takaki S, Tsuji K, Chayama K.
  • Journal Title: J Gastroenterol. Volume: 52 Issue: 4 Pages: 504-511
  • DOI: 10.1007/s00535-016-1255-4
  • Peer Reviewed / Open Access
• [Journal Article] Real-world efficacy and safety of daclatasvir and asunaprevir therapy for hepatitis C virus-infected cirrhosis patients. (2017)
  • Author(s): Morio K, Imamura M, Kawakami Y, Morio R, Kobayashi T, Yokoyama S, Nagaoki Y, Kawaoka T, Tsuge M, Hiramatsu A, Makokha GN, Hayes CN, Aikata H, Miki D, Ochi H, Honda Y, Mori N, Takaki S, Tsuji K, Chayama K.
  • Journal Title: J Gastroenterol Hepatol. Volume: 32 Issue: 3 Pages: 645-650
  • DOI: 10.1111/jgh.13511
  • Peer Reviewed
• [Journal Article] IFNL4 polymorphism effects on outcome of simeprevir, peginterferon, and ribavirin therapy for older patients with genotype 1 chronic hepatitis C. (2017)
  • Author(s): Mori N, Imamura M, Kawakami Y, Nagaoki Y, Kawaoka T, Tsuge M, Hiramatsu A, Hayes CN, Aikata H, Miki D, Ochi H, Honda Y, Takaki S, Tsuji K, Chayama K; Hiroshima Liver Study Group.
  • Journal Title: Hepatol Res. Volume: 47 Issue: 3
  • DOI: 10.1111/hepr.12715
  • Peer Reviewed
• [Journal Article] Association between variants in the interferon lambda 4 locus and substitutions in the hepatitis C virus non-structural protein 5A. (2015)
  • Author(s): Akamatsu S, Hayes CN, Ochi H, Uchida T, Kan H, Murakami E, Abe H, Tsuge M, Miki D, Akiyama R, Hiraga N, Imamura M, Aikata H, Kawaoka T, Kawakami Y, Chayama K.
  • Journal Title: J Hepatol. Volume: 63 Issue: 3 Pages: 554-563
  • DOI: 10.1016/j.jhep.2015.03.033
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Rapid, Sensitive, and Accurate Evaluation of Drug Resistant Mutant (NS5A-Y93H) Strain Frequency in Genotype 1b HCV by Invader Assay (2015)
  • Author(s): Satoshi Yoshimi, Hidenori Ochi, Eisuke Murakami, Takuro Uchida, Hiromi Kan, Sakura Akamatsu, C. Nelson Hayes, Hiromi Abe, Daiki Miki, Nobuhiko Hiraga, Michio Imamura, Hiroshi Aikata, Kazuaki Chayama.
  • Journal Title: PLOS ONE Volume: 10 Issue: 6 Pages: e0130022-e0130022
  • DOI: 10.1371/journal.pone.0130022
  • Peer Reviewed / Open Access
• [Journal Article] Circulating tumor DNA analysis for liver cancers and its usefulness as a liquid biopsy. (2015)
  • Author(s): Ono A, Fujimoto A, Yamamoto Y, Akamatsu S, Nobuhiko H, Imamura M, Kawaoka T, Tsuge M, Abe H, Hayes CN, Miki D, Furuta M, Tsunoda T, Miyano S, Kubo M, Aikata H, Ochi H, Kawakami Y, Arihiro K, Ohdan H, Nakagawa H, Chayama K
  • Journal Title: Cellular and Molecular Gastroenterology and Hepatology Volume: 1 Issue: 5 Pages: 516-534
  • DOI: 10.1016/j.jcmgh.2015.06.009
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Differences in serum microRNA profiles in hepatitis B and C virus infection. (2015)
  • Author(s): Akamatsu S, Hayes CN, Tsuge M, Miki D, Akiyama R, Abe H, Ochi H, Hiraga N, Imamura M, Takahashi S, Aikata H, Kawaoka T, Kawakami Y, Ohishi W, Chayama K.
  • Journal Title: J Infect. Volume: 70 Issue: 3 Pages: 273-287
  • DOI: 10.1016/j.jinf.2014.10.017
  • Peer Reviewed
• [Journal Article] The effects of bisphosphonate zoledronic acid in hepatocellular carcinoma, depending on mevalonate pathway. (2015)
  • Author(s): Honda Y, Takahashi S, Zhang Y, Ono A, Murakami E, Shi N, Kawaoka T, Miki D, Tsuge M, Hiraga N, Abe H, Ochi H, Imamura M, Aikata H, Chayama K.
  • Journal Title: J Gastroenterol Hepatol. Volume: 30 Issue: 3 Pages: 619-627
  • DOI: 10.1111/jgh.12715
  • Peer Reviewed / Open Access
• [Journal Article] Ribavirin dose reduction during telaprevir/ribavirin/peg-interferon therapy overcomes the effect of the ITPA gene polymorphism. (2014)
  • Author(s): Akamatsu S, Hayes CN, Tsuge M, Murakami E, Hiraga N, Abe H, Miki D, Imamura M, Ochi H, Chayama K; Hiroshima Liver Study Group.
  • Journal Title: J Viral Hepat. Volume: 22 Issue: 2 Pages: 166-174
  • DOI: 10.1111/jvh.12275
  • Peer Reviewed
• [Journal Article] Emergence of resistant variants detected by ultra-deep sequencing after asunaprevir and daclatasvir combination therapy in patients infected with hepatitis C virus genotype 1. (2014)
  • Author(s): Kosaka K, Imamura M, Hayes CN, Abe H, Hiraga N, Yoshimi S, Murakami E, Kawaoka T, Tsuge M, Aikata H, Miki D, Ochi H, Matsui H, Kanai A, Inaba T, Chayama K.
  • Journal Title: J Viral Hepat. Volume: 22 Issue: 2 Pages: 158-165
  • DOI: 10.1111/jvh.12271
  • Peer Reviewed / Open Access
• [Journal Article] Quantitative effect of natural killer-cell licensing on hepatocellular carcinoma recurrence after curative hepatectomy (2014)
  • Author(s): Tanimine N, Tanaka Y, Kobayashi T, Tashiro H, Miki D, Imamura M, Aikata H, Tanaka J, Chayama K, Ohdan H.
  • Journal Title: Cancer Immunol Res Volume: 2(12) Issue: 12 Pages: 1142-1147
  • DOI: 10.1158/2326-6066.cir-14-0091
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Two patients treated with pegylated interferon/ribavirin/telaprevir triple therapy for recurrent hepatitis C after living donor liver transplantation. (2014)
  • Author(s): Kawaoka T. Takahashi S. Tatsukawa Y. Hiramatsu A. Hiraga N. Miki D. Tsuge M. Imamura M. Kawakami Y. Aikata H. Ochi H. Ishiyama K. Ide K. Tashiro H. Ohdan H, and Chayama K
  • Journal Title: Hepatol Res Volume: 印刷中 Issue: 12 Pages: 1259-1264
  • DOI: 10.1111/hepr.12296
  • Peer Reviewed / Open Access
• [Journal Article] Human microRNA hsa-miR-1231 suppresses hepatitis B virus replication by targeting core mRNA. (2014)
  • Author(s): Kohno T, Tsuge M, Murakami E, Hiraga N, Abe H, Miki D, Imamura M, Ochi H, Hayes CN, Chayama K.
  • Journal Title: J Viral Hepat Volume: 21(9) Issue: 9
  • DOI: 10.1111/jvh.12240
  • Peer Reviewed
• [Journal Article] interferon lambda 4/interleukin-28B haplotype structure and its impact on susceptibility to hepatitis C virus and treatment response in the Japanese population (2014)
  • Author(s): Ochi H, Miki D, Hayes CN, Abe H, Hayashida Y, Kubo M, Chayama K
  • Journal Title: Journal of General Virology Volume: 95巻 Issue: 6 Pages: 1297-306
  • DOI: 10.1099/vir.0.060103-0
  • Peer Reviewed
• [Journal Article] Ultradeep sequencing study of chronic hepatitis C virus genotype 1 infection in patients treated with daclatasvir, peginterferon, and ribavirin (2014)
  • Author(s): Murakami, E. Imamura, M. Hayes, C. N. Abe, H. Hiraga, N. Honda, Y. Ono, A. Kosaka, K. Kawaoka, T. Tsuge, M. Aikata, H. Takahashi, S. Miki, D. Ochi, H. Matsui, H. Kanai, A. Inaba, T. McPhee, F. Chayama, K.
  • Journal Title: Antimicrob Agents Chemother Volume: 58 Issue: 4 Pages: 2105-2112
  • DOI: 10.1128/aac.02068-13
  • Peer Reviewed / Open Access
• [Journal Article] Predictive value of the IFNL4 polymorphism on outcome of telaprevir, peginterferon, and ribavirin therapy for older patients with genotype 1b chronic hepatitis C (2013)
  • Author(s): Fujino H. Imamura M. Nagaoki Y. Kawakami Y. Abe H. Hayes C N.et al
  • Journal Title: J Gastroenterol Volume: 電子書籍 Issue: 12 Pages: 1548-1556
  • DOI: 10.1007/s00535-013-0924-9
  • Peer Reviewed / Open Access
• [Presentation] B型慢性肝炎病勢評価のための新規マーカーとしてのマイクロRNAの可能性 (2016)
  • Author(s): 三木大樹、柘植雅貴、茶山一彰
  • Organizer: 第52回日本肝臓学会総会
  • Place of Presentation: 東京ベイ幕張ホール（千葉県千葉市）
  • Year and Date: 2016-05-19
• [Presentation] Japanese genetic study could not suggest the importance of the NTCP locus for HBV persistence. (2016)
  • Author(s): Miki D, Ochi H, Hayes CN, Abe H, Akamatsu S, Ono A, Nakahara T, Zhang Y, Masaki K, Fujino H, Miyaki E, Kan H, Uchida T, Hiraga N, Tsuge M, Kawaoka T, Imamura M, Kawakami Y, Aikata H, Chayama K.
  • Organizer: The 25th Conference of the Asian Pacific Association for the Study of the Liver (APASL2016).
  • Place of Presentation: Tokyo, Japan.
  • Year and Date: 2016-02-22
  • Int'l Joint Research
• [Presentation] The relationship between hepatocellular carcinoma development and reduced expression levels of the major germline genotype of PROSC, which is frequently deleted in hepatocellular carcinoma. (2015)
  • Author(s): Miki D, Ochi H, Hayes CN, Abe H, Akamatsu S, Ono A, Nakahara T, Zhang Y, Masaki K, Fujino H, Miyaki E, Kan H, Uchida T, Hiraga N, Tsuge M, Kawaoka T, Imamura M, Kawakami Y, Aikata H, Chayama K.
  • Organizer: The Liver Meeting 2015.
  • Place of Presentation: San Francisco, USA.
  • Year and Date: 2015-11-17
  • Int'l Joint Research
• [Presentation] Rapid, sensitive, and accurate evaluation system for drug resistant strain (NS5A-Y93H) frequency in genotype 1b HCV. (2015)
  • Author(s): Ochi H, Yoshimi S, Murakami E, Uchida T, Kan H, Akamatsu S, Hayes CN, Abe H, Miki D, Hiraga N, Imamura M, Aikata H, Chayama K.
  • Organizer: The Liver Meeting 2015.
  • Place of Presentation: San Francisco, USA.
  • Year and Date: 2015-11-17
  • Int'l Joint Research
• [Presentation] Circulating tumor DNA analysis for liver cancers and its usefulness as a liquid biopsy. (2015)
  • Author(s): Ono A, Hayes CN, Uchida T, Kan H, Masaki K, Nakahara T, Miki D, Kawaoka T, Tsuge M, Hiraga N, Imamura M, Kawakami Y, Aikata H, Ochi H, Abe H, Nakagawa H, Chayama K.
  • Organizer: The Liver Meeting 2015.
  • Place of Presentation: San Francisco, USA.
  • Year and Date: 2015-11-17
  • Int'l Joint Research
• [Presentation] Genetic association study failed to confirm an association between the NTCP S267F mutation and persistence of hepatitis B virus or development of hepatocellular carcinoma in the Japanese population. (2015)
  • Author(s): Miki D, Ochi H, Hayes CN, Abe H, Akamatsu S, Ono A, Nakahara T, Zhang Y, Masaki K, Fujino H, Miyaki E, Kan H, Uchida T, Hiraga N, Tsuge M, Kawaoka T, Imamura M, Kawakami Y, Aikata H, Chayama K.
  • Organizer: The Liver Meeting 2015.
  • Place of Presentation: San Francisco, USA.
  • Year and Date: 2015-11-16
  • Int'l Joint Research
• [Presentation] Genome-wide scan of miRNA polymorphisms revealed a suggestive association of miR-3143 with chronic hepatitis B virus infection. (2015)
  • Author(s): Miki D, Ochi H, Hayes CN, Abe H, Akamatsu S, Ono A, Nakahara T, Zhang Y, Masaki K, Fujino H, Miyaki E, Kan H, Uchida T, Hiraga N, Tsuge M, Kawaoka T, Imamura M, Kawakami Y, Aikata H, Chayama K.
  • Organizer: The Liver Meeting 2015.
  • Place of Presentation: San Francisco, USA.
  • Year and Date: 2015-11-16
  • Int'l Joint Research
• [Presentation] Difference of intracellular responses by HBV genotype A and C infection in humanized mouse model. (2015)
  • Author(s): Tsuge M, Hiraga N, Abe H, Imamura M, Miki D, Ochi H, Hayes CN, Chayama K.
  • Organizer: The Liver Meeting 2015.
  • Place of Presentation: San Francisco, USA.
  • Year and Date: 2015-11-16
  • Int'l Joint Research
• [Presentation] The impact of HLA-DQs and IFNL4 variant on hepatitis C virus-induced liver inflammation. (2015)
  • Author(s): Miki D, Ochi H, Hayes CN, Abe H, Akamatsu S, Ono A, Nakahara T, Zhang Y, Masaki K, Fujino H, Miyaki E, Kan H, Uchida T, Hiraga N, Tsuge M, Kawaoka T, Imamura M, Kawakami Y, Aikata H, Chayama K.
  • Organizer: The Liver Meeting 2015.
  • Place of Presentation: San Francisco, USA.
  • Year and Date: 2015-11-15
  • Int'l Joint Research
• [Presentation] Involvement of Endoplasmic Reticulum Stress Transducer BBF2H7 in Hepatocellular Carcinoma Promotion. (2015)
  • Author(s): Zhang Y, Hayes CN, Tsuge M, Hiraga N, Uchida T, Miki D, Abe H, Chayama K.
  • Organizer: The Liver Meeting 2015.
  • Place of Presentation: San Francisco, USA.
  • Year and Date: 2015-11-14
  • Int'l Joint Research
• [Presentation] 肝癌で欠損がみられる遺伝子の生殖細胞系列多型は自身の発現量を調節することで発癌に寄与しうる． (2015)
  • Author(s): 三木大樹、相方浩、大野敦司、卜部祐司、柘植雅貴、川上由育、久保充明、中村祐輔、茶山一彰．
  • Organizer: 第74回日本癌学会学術総会．
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Presentation] HBV感染に伴うmicroRNA発現変化とmiRNAによるHBV複製制御． (2015)
  • Author(s): 柘植雅貴、平賀伸彦、村上英介、阿部弘美、三木大樹、河岡友和、平松憲、今村道雄、兵庫秀幸、川上由育、相方浩、越智秀典、茶山一彰．
  • Organizer: 第51回日本肝臓学会総会．
  • Place of Presentation: 熊本
  • Year and Date: 2015-05-22
• [Presentation] HCV慢性感染肝組織内でのOAS1発現は自身近傍のSNPよりもIL28B近傍のSNPにより強く調節される． (2015)
  • Author(s): 三木大樹、阿部弘美、ヘイズ・ネルソン、越智秀典、河岡友和、大野敦司、中原隆志、村上英介、柾木慶一、内田宅郎、菅宏美、柘植雅貴、平賀伸彦、今村道雄、川上由育、相方浩、茶山一彰．
  • Organizer: 第51回日本肝臓学会総会．
  • Place of Presentation: 熊本
  • Year and Date: 2015-05-21
• [Presentation] HCV持続感染におけるIFNL4とHLA-DQの遺伝子多型間相互作用． (2015)
  • Author(s): 三木大樹、越智秀典、阿部弘美、大野敦司、中原隆志、柾木慶一、村上英介、内田宅郎、菅宏美、河岡友和、柘植雅貴、平賀伸彦、今村道雄、川上由育、相方浩、茶山一彰．
  • Organizer: 第101回日本消化器病学会総会．
  • Place of Presentation: 仙台
  • Year and Date: 2015-04-23
• [Presentation] A single amino acid substitution in HLA-DQB1 as well as an IFNL4 variant strongly affect susceptibility to chronic hepatitis C． (2014)
  • Author(s): Miki D, Ochi H, Takahashi A, Hayes CN, Urabe Y, Abe H, et al．
  • Organizer: The Liver Meeting 2014.
  • Place of Presentation: Boston, USA.
  • Year and Date: 2014-11-11
• [Presentation] The IL28B SNP has a stronger regulatory effect on the expression of OAS1 than a nearby SNP located downstream of OAS1 in chronic HCV patients． (2014)
  • Author(s): Miki D, Abe H, Hayes CN, Ochi H, Kawaoka T, Akamatsu S, Ono A, Nakahara T, Seki N, Murakami E, Zhang Y, Uchida T, Honda Y, Masaki K, Kan H, Tsuge M, Hiraga N, Imamura M, Kawakami Y, Aikata H, Kubo M, Chayama K．
  • Organizer: The Liver Meeting 2014.
  • Place of Presentation: Boston, USA.
  • Year and Date: 2014-11-11
• [Presentation] Hepatitis B virus infection efficiency and immune response decreases with cell density in primary cultured hepatocytes． (2014)
  • Author(s): Hayes CN, Abe H, Akamatsu S, Hiraga N, Imamura M, Tsuge M, Miki D, Aikata H, Ochi H, Ishida Y, Tateno C, Chayama K．
  • Organizer: The Liver Meeting 2014.
  • Place of Presentation: Boston, USA.
  • Year and Date: 2014-11-11
• [Presentation] Nucleotide analogue improves interferon responsiveness in HBV-infected human hepatocytes． (2014)
  • Author(s): Tsuge M, Hiraga N, Murakami E, Imamura M, Abe H, Miki D, Ochi H, Hayes CN, Chayama K．
  • Organizer: The Liver Meeting 2014.
  • Place of Presentation: Boston, USA.
  • Year and Date: 2014-11-11
• [Presentation] Pretreatment induction of ISGs in the presence of IFNL4 in hepatocytes but not in white blood cells is related with poor induction of ISGs following IFN-α therapy． (2014)
  • Author(s): Abe H, Hayes CN, Hiraga N, Imamura M, Tsuge M, Miki D, Aikata H, Ochi H, Ishida Y, Tateno C, Yoshizato K, Chayama K．
  • Organizer: The Liver Meeting 2014.
  • Place of Presentation: Boston, USA.
  • Year and Date: 2014-11-11
• [Presentation] Two microRNA polymorphisms are associated with hepatitis B virus-related but not hepatitis C virus-related hepatocellular carcinoma in the Japanese population． (2014)
  • Author(s): Miki D, Ochi H, Hayes CN, Abe H, Kawaoka T, Ono A, Akamatsu S, Nakahara T, Seki N, Murakami E, Zhang Y, Uchida T, Honda Y, Masaki K, Kan H, Tsuge M, Hiraga N, Imamura M, Kawakami Y, Aikata H, Kubo M, Chayama K．
  • Organizer: The Liver Meeting 2014.
  • Place of Presentation: Boston, USA.
  • Year and Date: 2014-11-09
• [Presentation] Germline variants of highly point-mutated genes in hepatocellular carcinoma do not have strong effects on HCV-related hepatocarcinogenesis． (2014)
  • Author(s): Miki D, Ochi H, Hayes CN, Ono A, Akamatsu S, Y. Urabe, Masaki K, Abe H, Kawaoka T, Nakahara T, Seki N, Murakami E, Zhang Y, Uchida T, Honda Y, Kan H, Tsuge M, Hiraga N, Imamura M, Kawakami Y, Aikata H, Kubo M, Chayama K．
  • Organizer: The Liver Meeting 2014.
  • Place of Presentation: Boston, USA.
  • Year and Date: 2014-11-09
• [Presentation] IFNL4/IL-28B haplotype structure and predictability of their variations for spontaneous and treatment-induced clearance of HCV infection in the Japanese population． (2014)
  • Author(s): Ochi H, Miki D, Hayes CN, Abe H, Kubo M, Chayama K．
  • Organizer: The Liver Meeting 2014.
  • Place of Presentation: Boston, USA.
  • Year and Date: 2014-11-09
• [Presentation] わが国におけるmiR-146aおよびmiR-196a2の遺伝子多型と肝炎ウイルス関連肝発癌リスク． (2014)
  • Author(s): 三木大樹、相方浩、大野敦司、卜部祐司、柘植雅貴、川上由育、久保充明、中村祐輔、茶山一彰．
  • Organizer: 第73回日本癌学会学術総会．
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-26
• [Presentation] HCV慢性化におけるHLA-DQB1の重要性：ゲノムワイド関連解析． (2014)
  • Author(s): 三木大樹、越智秀典、ヘイズ・ネルソン、阿部弘美、大野敦司、中原隆志、村上英介、河岡友和、柘植雅貴、平賀伸彦、今村道雄、川上由育、相方浩、高橋祥一、茶山一彰．
  • Organizer: 第50回日本肝臓学会総会．
  • Place of Presentation: 東京
  • Year and Date: 2014-05-30
• [Presentation] HCV感染におけるIFNL4の多型の違いによるIFN-λsの発現量とインターフェロン投与前後のインターフェロン誘導遺伝子の発現量の関係． (2014)
  • Author(s): 阿部弘美、三木大樹、平賀伸彦、今村道雄、柘植雅貴、小林知樹、河岡友和、川上由育、相方浩、越智秀典、茶山一彰．
  • Organizer: 第50回日本肝臓学会総会．
  • Place of Presentation: 東京
  • Year and Date: 2014-05-30
• [Presentation] HCV関連肝疾患におけるIFNL3(IL28B),IFNL4遺伝子型乖離例の頻度と抗ウイルス療法の効果の検討． (2014)
  • Author(s): 狩野吉康、山口将功、木村睦海、荒川智宏、中島知明、桑田靖昭、小関至、佐藤隆啓、大村卓味、髭修平、豊田成司、三木大樹、越智秀典、茶山一彰．
  • Organizer: 第50回日本肝臓学会総会．
  • Place of Presentation: 東京
  • Year and Date: 2014-05-30
• [Presentation] 当院におけるHBs抗原陰性化例の解析． (2014)
  • Author(s): 村上英介、柘植雅貴、藤野初枝、菅宏美、福原崇之、小林知樹、本田洋士、中原隆志、苗代典昭、大野敦司、宮木大輔、三木大樹、河岡友和、平賀伸彦、平松憲、今村道雄、兵庫秀幸、川上由育、相方浩、茶山一彰．
  • Organizer: 第50回日本肝臓学会総会．
  • Place of Presentation: 東京
  • Year and Date: 2014-05-29