Research Project
Grant-in-Aid for Young Scientists (B)
There are distinct mechanisms for viral sensing in the early phase of infection with hepatitis B virus (HBV) and hepatitis C virus (HCV). The former is DNA virus and the latter is RNA virus. In this study, we investigated genetic polymorphisms in viral sensing pathway affecting development of diseases caused by hepatitis viruses. NTCP was recently identified as a hepatocyte receptor for HBV. It has been reported that the amino acid substitution S267F, which corresponds to a single nucleotide polymorphism (SNP) rs2296651, of NTCP is defective in HBV receptor function. However, we found that the SNP is rare and could not find any genetic association between the SNP and HBV persistence nor development of HBV-induced HCC in Japanese population. We also investigated polymorphism of viral RNA sensor RIG-I, and found a supportive data for the theory that RIG-I functions not only as a RNA sensor but as a DNA sensor.
All 2017 2016 2015 2014 2013
All Journal Article (17 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 17 results, Open Access: 8 results, Acknowledgement Compliant: 2 results) Presentation (27 results) (of which Int'l Joint Research: 9 results)
J Med Virol.
Volume: 89 Issue: 4 Pages: 665-671
10.1002/jmv.24679
J Gastroenterol.
Volume: 52 Issue: 4 Pages: 504-511
10.1007/s00535-016-1255-4
J Gastroenterol Hepatol.
Volume: 32 Issue: 3 Pages: 645-650
10.1111/jgh.13511
Hepatol Res.
Volume: 47 Issue: 3
10.1111/hepr.12715
J Hepatol.
Volume: 63 Issue: 3 Pages: 554-563
10.1016/j.jhep.2015.03.033
PLOS ONE
Volume: 10 Issue: 6 Pages: e0130022-e0130022
10.1371/journal.pone.0130022
Cellular and Molecular Gastroenterology and Hepatology
Volume: 1 Issue: 5 Pages: 516-534
10.1016/j.jcmgh.2015.06.009
J Infect.
Volume: 70 Issue: 3 Pages: 273-287
10.1016/j.jinf.2014.10.017
Volume: 30 Issue: 3 Pages: 619-627
10.1111/jgh.12715
J Viral Hepat.
Volume: 22 Issue: 2 Pages: 166-174
10.1111/jvh.12275
Volume: 22 Issue: 2 Pages: 158-165
10.1111/jvh.12271
Cancer Immunol Res
Volume: 2(12) Issue: 12 Pages: 1142-1147
10.1158/2326-6066.cir-14-0091
Hepatol Res
Volume: 印刷中 Issue: 12 Pages: 1259-1264
10.1111/hepr.12296
J Viral Hepat
Volume: 21(9) Issue: 9
10.1111/jvh.12240
Journal of General Virology
Volume: 95巻 Issue: 6 Pages: 1297-306
10.1099/vir.0.060103-0
Antimicrob Agents Chemother
Volume: 58 Issue: 4 Pages: 2105-2112
10.1128/aac.02068-13
J Gastroenterol
Volume: 電子書籍 Issue: 12 Pages: 1548-1556
10.1007/s00535-013-0924-9