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Is FGFR2 fusion real target for bile tract cancer patients?

Research Project

Project/Area Number 26860537
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionNational Cancer Center Japan

Principal Investigator

Shunsuke Kondo  国立研究開発法人国立がん研究センター, その他部局等, 研究員 (90546201)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords胆道がん / FGFR / 融合遺伝子 / 分子標的治療 / 阻害剤 / 分子標的治療薬
Outline of Final Research Achievements

In vitro assay using with cell lines of bile tract cancer, we conducted the stable of overexpression with FGFR2 fusion (FGFR2-AHCYL1& FGFR2-BICC1). We validated dephosphorylation of the stable cell lines. On the other hands, several biological changes were not observed between overexpression model and endogenous cell lines. Therefore, we have challenged established cell lines from the surgical specimens. In parallel, we have detected FGFR gene mutations and FGFR fusion genes using next generation sequencer. The clinical project, TOP-GEAR project, has been on going that screening of genomic profiles and matching target therapies.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2016

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results)

  • [Journal Article] Trends in the development of MET inhibitors for hepatocellular carcinoma.2016

    • Author(s)
      Okuma HS, Kondo S.
    • Journal Title

      Future Oncology

      Volume: 12 Issue: 10 Pages: 1275-1286

    • DOI

      10.2217/fon.16.3

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pancreatic neuroendocrine tumors: A single-center 20-year experience with 100 patients.2016

    • Author(s)
      Shiba S, Morizane C, Hiraoka N, Sasaki M, Koga F, Sakamoto Y, Kondo S, Ueno H, Ikeda M, Yamada T, Shimada K, Kosuge T, Okusaka T.
    • Journal Title

      Pancreatology

      Volume: 16 Issue: 1 Pages: 99-105

    • DOI

      10.1016/j.pan.2015.11.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phase I clinical trial of oral administration of S-1 in combination with intravenous gemcitabine and cisplatin in patients with advanced biliary tract cancer.2016

    • Author(s)
      Shoji H, Morizane C, Sakamoto Y, Kondo S, Ueno H, Takahashi H, Ohno I, Shimizu S, Mitsunaga S, Ikeda M, Okusaka T.
    • Journal Title

      Japanese journal of clinical oncology

      Volume: 46 Pages: 132-137

    • DOI

      10.1093/jjco/hyv179

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] C-Reactive Protein Level Is an Indicator of the Aggressiveness of Advanced Pancreatic Cancer.2016

    • Author(s)
      Mitsunaga S, Ikeda M, Shimizu S, Ohno I, Takahashi H, Okuyama H, Ueno H, Morizane C, Kondo S, Sakamoto Y, Okusaka T, Ochiai A.
    • Journal Title

      Pancreas

      Volume: 45 Issue: 1 Pages: 110-116

    • DOI

      10.1097/mpa.0000000000000465

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access

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Published: 2014-04-04   Modified: 2017-05-10  

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