The role of autophagy in gastrointestinal carcinogenesis
| Project/Area Number |
26860538
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | The Institute for Adult Diseases Asahi Life Foundation |
|---|
Principal Investigator |
Kosuke Sakitani 公益財団法人朝日生命成人病研究所, その他部局等, その他 (60631299)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 大腸癌 / オートファジー / 小胞体ストレス / アポトーシス / p53 / 分子標的治療 / クロロキン / HCT116 |
|---|
| Outline of Final Research Achievements |
We showed that suppression of autophagy in colon cancer cells caused anti-tumor effects via enhanced apoptosis through p53 and unfolded protein response (UPR) activation. In addition, our study implies that suppressing UPR pathway is a valid strategy when colon cancer cells with mutant p53 are resistant to autophagic inhibition.
|
Report
(3 results)
Research Products
(2 results)
-
[Journal Article] Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress.2015
Author(s)
Sakitani K, Hirata Y, Hikiba Y, Hayakawa Y, Ihara S, Suzuki H, Suzuki N, Serizawa T, Kinoshita H, Sakamoto K, Nakagawa H, Tateishi K, Maeda S, Ikenoue T, Kawazu S, Koike K.
-
Journal Title
BMC Cancer
Volume: １５
Issue: 1
Pages: 795-808
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
