The role of autophagy in gastrointestinal carcinogenesis

Research Project

Project/Area Number	26860538
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Gastroenterology
Research Institution	The Institute for Adult Diseases Asahi Life Foundation
Principal Investigator	Kosuke Sakitani 公益財団法人朝日生命成人病研究所, その他部局等, その他 (60631299)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	大腸癌 / オートファジー / 小胞体ストレス / アポトーシス / p53 / 分子標的治療 / クロロキン / HCT116
Outline of Final Research Achievements	We showed that suppression of autophagy in colon cancer cells caused anti-tumor effects via enhanced apoptosis through p53 and unfolded protein response (UPR) activation. In addition, our study implies that suppressing UPR pathway is a valid strategy when colon cancer cells with mutant p53 are resistant to autophagic inhibition.

Report

(3 results)