| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The association between cardiac disease and serum IgG4 levels was analyzed. Serum levels of IgG4 had a significant association with coronary low-density plaque and epicardial fat volume. Patients with elevated serum IgG4 levels who were not angiographically diagnosed with coronary artery stenosis had a significantly higher subsequent risk of cardiovascular events than those without. In addition, among patients who received percutaneous coronary interventions, elevated serum IgG4 level was a significant predictor of major adverse cardiac events, including death, acute coronary syndrome, cerebral stroke, and target vessel revascularization, independent of traditional cardiovascular risk factors and serum hsCRP levels. IgG4-related immuno-inflammation may play a role in the development and progression of coronary atherosclerosis.
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