The role of p53 signaling in the progression of heart failure
Project/Area Number |
26860548
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular medicine
|
Research Institution | Niigata University |
Principal Investigator |
Yoshida Yohko 新潟大学, 医歯(薬)学総合研究科, 特任助教 (00586232)
|
Research Collaborator |
MINAMINO Tohru
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 心不全 / 老化 / 炎症 |
Outline of Final Research Achievements |
The p53 signaling pathway has been implicated in heart failure, but the pathological link between p53 and inflammation in the failing heart is largely unknown. In the present study, we found that expression of p53 was increased in cardiac endothelial cells and bone marrow cells in response to pressure overload, leading to up-regulation of intercellular adhesion molecule-1 (ICAM1) expression by endothelial cells and integrin expression by bone marrow cells. Norepinephrine markedly increased p53 expression in endothelial cells and macrophages. Reducing β2-adrenergic receptor expression in endothelial cells or bone marrow cells attenuated cardiac inflammation and improved systolic dysfunction during pressure overload. These results suggest that activation of the sympathetic nervous system promotes cardiac inflammation by up-regulating ICAM1 and integrin expression via p53 signaling to exacerbate cardiac dysfunction.
|
Report
(3 results)
Research Products
(8 results)
-
-
-
-
-
-
-
-
[Presentation] 心不全における血管内皮-骨髄老化シグナルの意義2014
Author(s)
吉田陽子, 清水逸平, 勝海悟郎, 須田将吉, 林由香, 池上龍太郎, 萱森裕美, 焦爽, 南野徹.
Organizer
第18回日本心不全学会学術集会
Place of Presentation
大阪国際会議場(大阪市)
Year and Date
2014-10-10 – 2014-10-12
Related Report