| Project/Area Number |
26860552
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Mie University |
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Principal Investigator |
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| Research Collaborator |
ITO Masaaki 三重大学, 大学院医学系研究科, 教授 (00223181)
DOHI Kaoru 三重大学, 医学部附属病院, 講師 (50422837)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 運動耐容能 / 心筋梗塞 / 糖尿病 / DPP4阻害薬 / DPP-4阻害薬 / 急性心筋梗塞 / 運動療法 / 心血管機能 / 2型糖尿病 |
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| Outline of Final Research Achievements |
Exercise training improves exercise capacity in patients with acute myocardial infarction. DPP-4（dipeptidyl peptidase-4) inhibitor was reported to improve left ventricular diastolic function. The purpose of the present study was to evaluate whether the combination of exercise training and DPP-4 inhibitor for 5 months could improve exercise capacity (peak oxygen uptake: peak VO2) and cardiovascular function more than exercise training alone in patients with acute myocardial infraction and diabetes mellitus. Although the number of patients was smaller than proposed, peak VO2 increased in both groups (time effect p=0.003, interaction effect p= 0.66). In exercise and DPP-4 inhibitor group, peak VO2 increased by 18%, while it increased by 12%in exercise alone. No changes were observed in cardiovascular function in both groups. These results may indicate that the addition of DPP-4 inhibitor may have little effect on exercise capacity and cardiovascular function.
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