Development of cardiomyocyte committed progenitor cell therapy for cardiac regeneration

Research Project

Project/Area Number	26860554
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Cardiovascular medicine
Research Institution	Kyoto University
Principal Investigator	Takeda Masafumi 京都大学, iPS細胞研究所, 研究員 (40547501)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	心臓再生 / 心筋再生 / 心筋前駆細胞治療
Outline of Final Research Achievements	We found a cell surface molecule successfully marked a cell population with features of cardiomyocyte-committed progenitors (we tentatively called the molecule as CCP). We generated CCP+ cardiac progenitor cell sheet and transplanted it to rat MI model. As a result, we observed cardiomyocytes derived from CCP+ cardiac progenitor cells within injured heart. These results suggested that CCP+ cardiac progenitor cells transplantation might be a promising therapy for cardiac regeneration.

Report

(3 results)