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Development of cardiomyocyte committed progenitor cell therapy for cardiac regeneration

Research Project

Project/Area Number 26860554
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cardiovascular medicine
Research InstitutionKyoto University

Principal Investigator

Takeda Masafumi  京都大学, iPS細胞研究所, 研究員 (40547501)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords心臓再生 / 心筋再生 / 心筋前駆細胞治療
Outline of Final Research Achievements

We found a cell surface molecule successfully marked a cell population with features of cardiomyocyte-committed progenitors (we tentatively called the molecule as CCP). We generated CCP+ cardiac progenitor cell sheet and transplanted it to rat MI model. As a result, we observed cardiomyocytes derived from CCP+ cardiac progenitor cells within injured heart. These results suggested that CCP+ cardiac progenitor cells transplantation might be a promising therapy for cardiac regeneration.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2016 2015

All Presentation (4 results)

  • [Presentation] Identification of hiPS-derived cardiomyocyte-committed progenitor (CCP) population as a promising cell source for cardiac regeneration2016

    • Author(s)
      武田 匡史
    • Organizer
      日本循環器病学会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヒトiPS細胞由来新規心筋特異的前駆細胞表面マーカーの同定2016

    • Author(s)
      武田 匡史
    • Organizer
      再生医療学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2016-03-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] ヒトiPS細胞由来新規心筋特異的前駆細胞表面マーカーの同2015

    • Author(s)
      武田 匡史
    • Organizer
      日本炎症再生医学会
    • Place of Presentation
      虎の門ヒルズフォーラム
    • Year and Date
      2015-07-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] iPS細胞由来新規心筋特異的前駆細胞表面マーカーの同定2015

    • Author(s)
      武田 匡史
    • Organizer
      第14回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-03-19 – 2015-03-21
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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