Analysis of Non-coding RNA Functions in Heart Diseases
Project/Area Number |
26860556
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular medicine
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Research Institution | Kyoto University |
Principal Investigator |
Yasuhide Kuwabara 京都大学, 医学(系)研究科(研究院), 助教 (60632099)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 心不全 / 非コードRNA / 心肥大 / マイクロRNA |
Outline of Final Research Achievements |
Heart failure is a clinical syndrome, in which the heart can not pump the blood necessary in whole organs. In this investigation, we focused on the protein non-coding RNAs and tried to figure out the molecular mechanisms underlying cardiac hypertrophy and heart failure. It is known that type 2 diabetes and obesity induce cardiac hypertrophy and heart failure. During this research period, we found that miR-451, which is one of the non-coding RNAs, exacerbated the cardiac hypertrophy induced by obesity and type 2 diabetes by using cardiomyocyte-specific miR-451 knockout mice. We also conducted the analysis of a long non-coding RNA, which is upregurated in heart failure, and got the interesting results.
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway.2015
Author(s)
Kuwabara Y, Horie T, Baba O, Watanabe S, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Otsu K, Kita T, Kimura T, Ono K.
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Journal Title
Circulation Research
Volume: 116
Issue: 2
Pages: 279-288
DOI
Related Report
Peer Reviewed
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[Journal Article] Expression Patterns of miRNA-423-5p in the Serum and Pericardial Fluid in Patients Undergoing Cardiac Surgery.2015
Author(s)
Miyamoto S, Usami S, Kuwabara Y, Horie T, Baba O, Hakuno D, Nakashima Y, Nishiga M, Izuhara M, Nakao T, Nishino T, Ide Y, Nakazeki F, Wang J, Ueyama K, Kimura T, Ono K.
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Journal Title
PLoS One.
Volume: 10(11)
Issue: 11
Pages: e0142904-e0142904
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] High-density lipoprotein cholesterol levels and cardiovascular outcomes in Japanese patients after percutaneous coronary intervention: a report from the CREDO-Kyoto registry cohort-2.2015
Author(s)
Izuhara M, Ono K, Shiomi H, Morimoto T, Furukawa Y, Nakagawa Y, Shizuta S, Tada T, Tazaki J, Horie T, Kuwabara Y, Baba O, Nishino T, Kita T, Kimura T; CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators.
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Journal Title
Atherosclerosis.
Volume: 242(2)
Issue: 2
Pages: 632-8
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] MicroRNA-33a/b in Lipid Metabolism2015
Author(s)
Ono K, Horie T, Nishino T, Baba O, Kuwabara Y, Yokode M, Kita T, Kimura T.
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Journal Title
Circulation Journal
Volume: 79
Issue: 2
Pages: 278-284
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Open Access
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[Journal Article] MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo.2014
Author(s)
Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Nakazeki F, Ide Y, Koyama S, Sowa N, Yahagi N, Shimano H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K.
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Journal Title
Scientific Reports
Volume: 4
Issue: 1
Pages: 5312-5312
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cardiac-Specific Inhibition of Kinase Activity in Calcium/Calmodulin-Dependent Protein Kinase Kinase-β Leads to Accelerated Left Ventricular Remodeling and Heart Failure after Transverse Aortic Constriction in Mice2014
Author(s)
Shin Watanabe, Takahiro Horie, Kazuya Nagao, Yasuhide Kuwabara, Osamu Baba, Hitoo Nishi, Naoya Sowa, Michiko Narazaki, Tetsuya Matsuda, Genzou Takemura, Hiromichi Wada, Koji Hasegawa, Takeshi Kimura, Koh Ono
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Journal Title
PLoS ONE
Volume: 9
Issue: 9
Pages: e108201-e108201
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] LincRNAs Regulated by Pressure-overload Induce Hypertrophy in Neonatal Mouse Cardiac Myocytes.2016
Author(s)
Kuwabara Y, Horie T, Baba O, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Ide Y, Nakazeki F, Koyama S, Kita T, Kimura T, Ono K.
Organizer
The 80th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
Sendai, Japan
Year and Date
2016-03-18
Related Report
Int'l Joint Research
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[Presentation] MicroRNA-451 Induced by Palmitate Aggravates Diabetic Cardiomyopathy via Suppression of the LKB1/AMPK Signaling Pathway.2015
Author(s)
Yasuhide Kuwabara, Takahiro Horie, Osamu Baba, Masayasu Izuhara, Shunsuke Usami, Tetsushi Nakao, Masataka Nishiga, Tomohiro Nishino, Yuya Ide, Fumiko Nakazeki, Satoshi Koyama, Koji Hasegawa, Toru Kita, Takeshi Kimura, Koh Ono.
Organizer
20th Asian Pacific Society of Cardiology Congress
Place of Presentation
Abu Dhabi, UAE
Year and Date
2015-04-29
Related Report
Int'l Joint Research
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[Presentation] MicroRNA-451 is Involved in Diabetic Cardiomyopathy through LKB1/AMPK Pathway.2015
Author(s)
Kuwabara Y, Horie T, Baba O, Nishiga M, Usami S, Izuhara M, Nakao T, Nishino T, Yuya Ide, Fumiko Nakazeki, Kimura T, Ono K.
Organizer
The 79th Annual Scientific Meeting of the Japanese Circulation Society,
Place of Presentation
Osaka, Japan
Year and Date
2015-04-24
Related Report
Int'l Joint Research
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[Presentation] MicroRNA-451 Exacerbates Lipotoxicity in Cardiomyocytes and High-Fat Diet-Induced Cardiac Hypertrophy in Mice through Suppression of the LKB1/AMPK Pathway.2015
Author(s)
Yasuhide Kuwabara, Takahiro Horie, Osamu Baba, Shin Watanabe, Toru Kita, Takeshi Kimura, Koh Ono.
Organizer
Keystone Symposia, Mitochondria, Metabolism and Heart Failure joint with Diabetes and Metabolic Dysfunction.
Place of Presentation
Santa Fe, New Mexico, USA
Year and Date
2015-01-27 – 2015-02-01
Related Report
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[Presentation] MicroRNA-451 is Involved in Diabetic Cardiomyopathy through Suppression of the LKB1/AMPK Pathway.2014
Author(s)
Yasuhide Kuwabara, Takahiro Horie, Osamu Baba, Masataka Nishiga, Shunsuke Usami, Masayasu Izuhara, Tetsushi Nakao, Tomohiro Nishino, Toru Kita, Takeshi Kimura, Koh Ono.
Organizer
9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress.
Place of Presentation
Kyoto, Japan
Year and Date
2014-09-12 – 2014-09-14
Related Report
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