| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Heart failure is the major cause of death in the developed countries. However, the precise mechanism of this disease is still unclear. Using several rat heart failure models, we identified periostin that is upregulated by ischemia and causes myocyte apoptosis by inhibiting cell attachment. Moreover, neutralizing antibody against specific alternative splicing isoform of periostin has been generated and its effect on ischemic heart failure has been proofed in this experiment. We are currently conducting additional experiment for future clinical application of this antibody.
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