| Project/Area Number |
26860569
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | baroreflex / heart failure / hemodynamics / pulmonary edema / HFpEF / circulatory equilibrium / 動脈圧反射 / 血圧制御 / 自律神経制御 / 心機能 / 血行動態 / 心不全 / 循環平衡 |
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| Outline of Final Research Achievements |
We defined the dynamic characteristics of the baroreflex (BR) regulation of the ventricular and vascular properties using the white noise method. Based on the concept of the ventriculo-arterial coupling and the framework of circulatory equilibrium, we reported that vascular properties (especially in stressed blood volume), not ventricular properties, predominantly contribute to BR regulation of arterial pressure. Based on this result, we hypothesized that BR failure may cause volume intolerance.
We evaluated the volume tolerance by infusion of dextran while measuring left atrial pressure, an index of pulmonary edema, in both normal BR and BR failure models. In BR failure, small amount of dextran led to marked increase of left atrial pressure suggesting that the BR failure is one of the main mechanism of flash pulmonary edema. This result may lead us to develop a new therapeutic strategy to treat heart failure with preserved ejection fraction.
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