Brain-derived neurotrophic factor and cardiac rehabilitation in patients with heart failure

• Project/Area Number: 26860574
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Kumamoto University (2016); National Cardiovascular Center Research Institute (2014-2015)
• Principal Investigator: Takashio Seiji 熊本大学, 医学部附属病院, 助教 (50573599)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: 心不全 / 抑うつ / リハビリテーション / 脳由来神経栄養因子 / BDNF / 心臓リハビリテーション / 抑鬱 / バイオマーカー / うつ

Outline of Final Research Achievements

Low levels of brain-derived neurotrophic factor (BDNF) potentially play a role in depression. Because depression is associated with increased risk of heart failure (HF), the pathogenic link between HF and depression has attracted clinical attention. We hypothesized that plasma BDNF levels might be decreased in patients with HF and cardiac rehabilitation might be increase BDNF levels in association with improvement of exercise tolerance and depressive symptom. Lower BDNF levels were associated with HF severity and higher incidences of all-cause mortality. After cardiac rehabilitation, plasma BDNF levels were significantly increased, which was associated with improvement of depressive symptom. However, we could not identify the relations between increase of BDNF level and improvement of exercise tolerance. These findings suggest that BDNF levels was decreased and cardiac rehabilitation can improve the depressive symptom with increase of BDNF levels in patients with HF.

Research Products

• [Journal Article] Significance of Low Plasma Levels of Brain-derived Neurotrophic Factor in Patients with Heart Failure (2015)
  • Author(s): Seiji Takashio, MD, PhD, Seigo Sugiyama MD, PhD, Megumi Yamamuro, MD, PhD, Hiroyuki Takahama MD, PhD, Tomohiro Hayashi MD, Yasuo Sugano MD, PhD, Yasuhiro Izumiya, MD, PhD, Seiji Hokimoto, MD, PhD, Naoto Minamino, MD, PhD, Satoshi Yasuda, MD, PhD, Toshihisa Anzai, MD, PhD, Hisao Ogawa, MD, PhD
  • Journal Title: American jornal of Cardiology Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Change of plasma brain-derived neurotrophic factor levels in acute decompensated heart failure (2015)
  • Author(s): Seiji Takashio, Hiroyuki Takahama, Tomohiro Hayashi, Naoto Minamino, Seigo Sugiyama, Satoshi Yasuda, Hisao Ogawa, Toshihisa Anzai
  • Organizer: 日本循環器学会学術総会2015年
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26