The function of sirt7 in lipid raft

Research Project

Project/Area Number	26860575
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Cardiovascular medicine
Research Institution	Kumamoto University
Principal Investigator	Araki Satoshi 熊本大学, 医学部附属病院, 助教 (20706717)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	Sirt7 / 線維化 / 心筋梗塞 / オートファジー / 線維芽細胞 / TGF
Outline of Final Research Achievements	Sirt7, 1 of the 7 members of the mammalian sirtuin family, promotes oncogenic transformation. We investigated the role of Sirt7 in cardiovascular tissue repair process. Compared with wild-type mice, homozygous Sirt7-deficient (Sirt7-/-) mice showed susceptibility to cardiac rupture after myocardial infarction. Sirt7-/- mice derived or Sirt7 siRNA treated cardiac fibroblasts showed reduction of transforming growth factor receptor I protein. Loss of Sirt7 activated autophagy in cardiac fibroblasts. Sirt7 maintains transforming growth factor receptor I by modulating autophagy and is involved in the tissue repair process.

Report

(3 results)