The function of sirt7 in lipid raft
Project/Area Number |
26860575
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular medicine
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Research Institution | Kumamoto University |
Principal Investigator |
Araki Satoshi 熊本大学, 医学部附属病院, 助教 (20706717)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | Sirt7 / 線維化 / 心筋梗塞 / オートファジー / 線維芽細胞 / TGF |
Outline of Final Research Achievements |
Sirt7, 1 of the 7 members of the mammalian sirtuin family, promotes oncogenic transformation. We investigated the role of Sirt7 in cardiovascular tissue repair process. Compared with wild-type mice, homozygous Sirt7-deficient (Sirt7-/-) mice showed susceptibility to cardiac rupture after myocardial infarction. Sirt7-/- mice derived or Sirt7 siRNA treated cardiac fibroblasts showed reduction of transforming growth factor receptor I protein. Loss of Sirt7 activated autophagy in cardiac fibroblasts. Sirt7 maintains transforming growth factor receptor I by modulating autophagy and is involved in the tissue repair process.
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Report
(3 results)
Research Products
(2 results)
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[Journal Article] Sirt7 Contributes to Myocardial Tissue Repair by Maintaining Transforming Growth Factor-β Signaling Pathway2015
Author(s)
Araki S, Izumiya Y, Rokutanda T, Ianni A, Hanatani S, Kimura Y, Onoue Y, Senokuchi T, Yoshizawa T, Yasuda O, Koitabashi N, Kurabayashi M, Braun T, Bober E, Yamagata K, Ogawa H
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Journal Title
Circulation
Volume: 132(12)
Issue: 12
Pages: 1081-1093
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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