| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Outline of Final Research Achievements |
In recent years, thrombosis patients were increasing in association with lifestyle related diseases. In this study, we attempeted to elucidate the role of NLRP3 inflammasome which is known to be involved in sterile inflammation in lifestyle-related diseases in arterial and deep vein thrombosis. Analysis of mice thrombosis model (middle cerebral artery thrombosis and caudal vena cava thrombosis), only ASC which is component of NLRP3 inflammsome deficient mice enhanced development of thrombosis compared with those in wild-type and other NLRP3 component deficient mice. In addition to more analysis, P-selectin was more likely to activation in ASC deficient platelets. ASC is expected to become a therapeutic target for thrombosis to clarify the mechanism.
|
