The exploratory research to investigate the novel anti-atherosclerotic factor using iPS cells
Project/Area Number |
26860583
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular medicine
|
Research Institution | Keio University |
Principal Investigator |
Kusumoto Dai 慶應義塾大学, 医学部(信濃町), 助教 (70571727)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | 動脈硬化 / iPS細胞 / 血管内皮細胞 / 血管内皮 |
Outline of Final Research Achievements |
Throughout our lives, we are exposed to cellular stress, which causes age-related diseases, such as metabolic syndromes, atherosclerosis, and cancer. Although we have evolved several innate protective mechanisms from cellular stress, the damage is often cumulative and irreversible. However, in rare cases, patients with strong chronic stress such as uncontrolled diabetes, exhibit minimal organ damage, suggesting that they would have strong innate protective mechanisms. Although there are several methods of genetic analysis, including genome-wide association study and exome sequencing, the vascular protective mechanisms are still unknown. In this study, we used the endothelial cells (ECs) derived from induced pluripotent stem cells (iPSCs) of severe diabetic patients with mild atherosclerosis to examine these innate protective mechanisms and explore a molecular target, to propose a novel vascular protective mechanism against cellular stresses.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Emerin plays a crucial role in nuclear invagination and in the nuclear calcium transient.2017
Author(s)
Shimojima M, Yuasa S, Motoda C, Yozu G, Nagai T, Ito S, Lachmann M, Kashimura S, Takei M, Kusumoto D, Kunitomi A, Hayashiji N, Seki T, Tohyama S, Hashimoto H, Kodaira M, Egashira T, Hayashi K, Nakanishi C, Sakata K, Yamagishi M, Fukuda K.
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 44312-44312
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] H1foo Has a Pivotal Role in Qualifying Induced Pluripotent Stem Cells2016
Author(s)
Kunitomi A, Yuasa S, Sugiyama F, Saito Y, Seki T, Kusumoto D, Kashimura S, Takei M, Tohyama S, Hashimoto H, Egashira T, Tanimoto Y, Mizuno S, Tanaka S, Okuno H, Yamazawa K, Watanabe H, Oda M, Kaneda R, Matsuzaki Y, Nagai T, Okano H, Yagami K, Tanaka M, Fukuda K.
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Journal Title
Stem Cell Reports
Volume: 6
Issue: 6
Pages: 825-833
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] G-CSF supports long-term muscle regeneration in mouse models of muscular dystrophy2015
Author(s)
Hayashiji N, Yuasa S, Miyagoe-Suzuki Y, Hara M, Ito N, Hashimoto H, Kusumoto D, Seki T, Tohyama S, Kodaira M, Kunitomi A, Kashimura S, Takei M, Saito Y, Okata S, Egashira T, Endo J, Sasaoka T, Takeda S, Fukuda K
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Journal Title
Nature Communications
Volume: 6
Issue: 1
Pages: 6745-6745
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Analysis of cardiomyocyte movement in the developing murine heart.2015
Author(s)
Hashimoto H, Yuasa S, Tabata H, Tohyama S, Seki T, Egashira T, Hayashiji N, Hattori F, Kusumoto D, Kunitomi A, Takei M, Kashimura S, Yozu G, Shimojima M, Motoda C, Muraoka N, Nakajima K, Sakaue-Sawano A, Miyawaki A, Fukuda K
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Journal Title
Biochem Biophys Res Commun
Volume: 464
Issue: 4
Pages: 1000-1007
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Endothelin-1 induces myofibrillar disarray and contractile vector variability in hypertrophic cardiomyopathy-induced pluripotent stem cell-derived cardiomyocytes2014
Author(s)
Tanaka A, Yuasa S, Mearini G, Egashira T, Seki T, Kodaira M, Kusumoto D, Kuroda Y, Okata S, Suzuki T, Inohara T, Arimura T, Makino S, Kimura K, Kimura A, Furukawa T, Carrier L, Node K, Fukuda K
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Journal Title
J Am Heart Assoc
Volume: 3
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Primate specific gene, POTEE has a protective role against vascular injury 1 in endothelial cells2017
Author(s)
Dai Kusumoto, Shinsuke Yuasa, Tomohisa Seki, Makoto Takei, Akira Kunitomi, Shin Kashimura, Shugo Tohyama, Chikaaki Motoda, Yoshikazu Kishino, Nozomi Hayashiji, Sarasa Isobe, Toshiya Tanaka, Koichiro Homma, Hiroshi Itoh, Keiichi Fukuda.
Organizer
第81回日本循環器学会学術集会
Place of Presentation
石川県金沢市 第4会場(ANAクラウンプラザ ヴィサージュ会議室 11F)
Year and Date
2017-03-17
Related Report