Genetic analysis of patients with hypertrophic cardiomyopathy using next generation sequencer
Project/Area Number |
26860584
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular medicine
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Research Institution | Keio University |
Principal Investigator |
Tanimoto Yoko 慶應義塾大学, 医学部, 助教 (50398616)
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Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 肥大型心筋症 / 遺伝子解析 / 次世代シークエンサー / 疾患特異的iPS細胞 |
Outline of Final Research Achievements |
From the database consisted of HCM patients visiting Keio University Hospital, DNA samples were collected after obtaining written infromed consent. The DNAs were analyzed by the next generation sequencer. The identified variant was also confirmed by Sanger method. Furthermore, the iPS cells delived from these patients were established by the standard iPS cell preparation method. Each cell lines: healthy human derived iPS cell line and HCM derived iPS cells were shifted to mass culture system .
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Predictive factors of lead failure in patients implanted with cardiac devices2015
Author(s)
Aizawa Y, Negishi M, Kashimura S, Nakajima K, Kunitomi A, Katsumata Y, Nishiyama T, Kimura T, Nishiyama N, Fukumoto K, Tanimoto Y, Kohsaka S, Takatsuki S, Fukuda K
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Journal Title
Int J Cardiol
Volume: 199
Pages: 277-81
Related Report
Peer Reviewed
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[Journal Article] Visualization of the left atrial appendage by phased-array intracardiac echocardiography from the pulmonary artery in patients with atrial fibrillation.2015
Author(s)
Nishiyama T, Katsumata Y, Inagawa K, Kimura T, Nishiyama N, Fukumoto K, Tanimoto Y, Aizawa Y, Tanimoto K, Fukuda K, Takatsuki S.
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Journal Title
Europace
Volume: 17
Issue: 4
Pages: 546-51
DOI
Related Report
Peer Reviewed
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[Journal Article] Risk factors for early replacement of cardiovascular implantable electronic devices2015
Author(s)
Aizawa Y, Kunitomi A, Nakajima K, Kashimura S, Katsumata Y, Nishiyama T, Kimura T, Nishiyama N, Tanimoto Y, Kohsaka S, Takatsuki S, Fukuda K
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Journal Title
Int J Cardiol
Volume: 178
Pages: 99-101
DOI
Related Report
Peer Reviewed
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[Journal Article] Operator-blinded contact force monitoring during pulmonary vein isolation using conventional and steerable sheaths.2014
Author(s)
Kimura T, Takatsuki S, Oishi A, Negishi M, Kashimura S, Katsumata Y, Nishiyama T, Nishiyama N, Tanimoto Y, Aizawa Y, Fukuda K.
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Journal Title
Int J Cardiol.
Volume: 177
Issue: 3
Pages: 970-6
DOI
Related Report
Peer Reviewed
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[Journal Article] Thoracic impedance as a therapeutic marker of acute decompensated heart failure.2014
Author(s)
Aizawa Y, Takatsuki S, Kashimura S, Katsumata Y, Nishiyama T, Kimura T, Nishiyama N, Tanimoto Y, Tanimoto K, Fukuda Y, Sato T, Ogawa S, Fukuda K.
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Journal Title
Int J Cardiol
Volume: 174
Issue: 3
Pages: 840-2
DOI
Related Report
Peer Reviewed
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[Journal Article] Serum Inflammation Markers Predicting Successful Initial Catheter Ablation for Atrial Fibrillation.2014
Author(s)
Kimura T, Takatsuki S, Inagawa K, Katsumata Y, Nishiyama T, Nishiyama N, Fukumoto K, Aizawa Y, Tanimoto Y, Tanimoto K, Fukuda K.
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Journal Title
Heart Lung Circ.
Volume: 14
Issue: 7
Pages: 636-43
DOI
Related Report
Peer Reviewed
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[Presentation] Clinical Characteristics, and Long-term Outcome of the Dilated Phase of Hypertrophic Cardiomyopathy2016
Author(s)
Yoshiyasu Aizawa, Yoko Tanimoto , Mitsushige Murata , Mai Kimura , Yoshinori Katsumata , Takahiko Nishiyama , Takehiro Kimura , Nobuhiro Nishiyama , Kotaro Fukumoto , Shinsuke Yuasa , Takashi Kohno , Shun Kohsaka , Shinji Makino , Motoaki Sano , Seiji Takatsuki , Keiichi Fukuda
Organizer
第80回日本循環器学会学術集会
Place of Presentation
国際センター会議棟(宮城県仙台市)
Year and Date
2016-03-18
Related Report
Int'l Joint Research
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[Presentation] High Incidence of Lead Failure in Patients with Brugada Syndrome and Idiopathic Ventricular Fibrillation2016
Author(s)
Yoshiyasu Aizawa, Seiji Takatsuki , Kazuaki Nakajima , Shin Kashimura , Akira Kunitomi , Yoshinori Katsumata , Takahiko Nishiyama , Takehiro Kimura , Nobuhiro Nishiyama , Kotaro Fukumoto , Yoko Tanimoto , Shun Kohsaka , Keiichi Fukuda
Organizer
第80回日本循環器学会学術集会
Place of Presentation
国際センター展示棟(宮城県仙台市)
Year and Date
2016-03-18
Related Report
Int'l Joint Research
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[Presentation] Comparison of circadian, weekly and seasonal Comparison of circadian, weekly and seasonal variations between electrical storms versus single VF events in patients with Brugada syndrome2015
Author(s)
Yoshiyasu Aizawa, Seiji Takatsuki, Yoshinori Katsumata, Takahiko Nishiyama, Nobuhiro Nishiyama, Kotaro Fukumoto, Yoko Tanimoto, Yoshiaki Kaneko, Shinichi Niwano, Takashi Kurita, Takeshi Mitsuhashi, Takashi Noda, Shiro Kamakura, Akihiko Shimizu, Minoru Horie, Yoshifusa Aizawa, Keiichi Fukuda
Organizer
第30回日本不整脈学会学術大会・第32回日本心電学会学術集会
Place of Presentation
グランドプリンスホテル京都(京都府京都市)
Year and Date
2015-07-28
Related Report
Int'l Joint Research
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[Presentation] Sex-dependency of Sick Sinus Syndrome Phenotype in Female Members of Familial Brugada Syndrome2015
Author(s)
Yoshiyasu Aizawa, Seiji Takatsuki, Seiko Ohno, Satoshi Nagase, Shogo Ito, Kazuaki Nakajima, Shin Kashimura, Akira Kunitomi, Yoshinori Katsumata, Takahiko Nishiyama, Takehiro Kimura, Nobuhiro Nishiyama, Yoko Tanimoto, Satoshi Ogawa, Kenjiro Kosaki, Keiichi Fukuda
Organizer
Heart Rhythm Society
Place of Presentation
ボストン(米国)
Year and Date
2015-05-13
Related Report
Int'l Joint Research
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