Aortic iron overload in abdominal aortic aneurysm

• Project/Area Number: 26860590
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Hyogo Medical University
• Principal Investigator: Sawada Hisashi 兵庫医科大学, 医学部, 助教 (00594764)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 腹部大動脈瘤 / 鉄 / 酸化ストレス / 炎症 / トランスフェリンレセプター

Outline of Final Research Achievements

We investigated whether iron is involved in AAA formation using human AAA tissues and murine AAA models. Iron was accumulated in human and murine AAA tissues compared with non-AAA tissues, and iron accumulated area was closed to oxidative stress marker positive area and macrophage infiltrated area. We next investigated the effects of dietary iron restriction on AAA formation in mice. Iron restriction reduced the incidence of AAA formation with attenuation of oxidative stress and inflammation in AAA mice. Aortic expression of TfR1, intracellular iron transport protein, was increased in human and murine AAA tissues. Iron is involved in AAA formation, and aortic iron metabolism may be a new therapeutic target for AAA formation.

Research Products

• [Journal Article] Aortic iron overload with oxidative stress and inflammation in human and murine abdominal aortic aneurysm. (2015)
  • Author(s): Hao H, Sawada T, Naito Y, Oboshi M, Hirotani S, Mitsuno M, Miyamoto Y, Hirota S, Masuyama T
  • Journal Title: Arteriosclerosis Thrombosis and Vascular Biology Volume: 35 Issue: 6 Pages: 1507-1514
  • DOI: 10.1161/atvbaha.115.305586
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Aortic Iron Overload with Oxidative Stress and Inflammation in Human and Murine Abdominal Aortic Aneurysm (2015)
  • Author(s): Sawada H, Hao H, Naito Y, Oboshi M, Hirotani S, Mitsuno M, Miyamoto Y, Hirota S, Masuyama T
  • Journal Title: Arteriosclerosis, Thrombosis, and Vascular Biology Volume: Epub
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] ヒト動脈硬化病変におけるトランスフェリンレセプター1 発現について. (2015)
  • Author(s): 澤田 悠, 内藤由朗, 大星真貴子, 曽山裕子, 西村晃一, 江口明世, 奥原祥貴, 森澤大祐, 岩破俊博, 廣谷信一, 真野敏昭, 羽尾裕之, 光野正孝, 廣田誠一, 宮本裕治, 増山 理.
  • Organizer: 第63回日本心臓病学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県、横浜市）
  • Year and Date: 2015-09-18
• [Presentation] Aortic Iron Overload in Human and Murine Abdominal Aortic Aneurysm (2015)
  • Author(s): 澤田 悠ほか13名
  • Organizer: 第79回 日本循環器学会 学術集会
  • Place of Presentation: グランフロント大阪
  • Year and Date: 2015-04-25
• [Presentation] Aortic Iron Overload in Human and Murine Abdominal Aortic Aneurysm. (2015)
  • Author(s): Sawada H, Naito Y, Oboshi M, Nishimura K, Eguchi A, Ando T, Morisawa D, Okuhara Y, Iwasaku T, Hirotani S, Mano T, Masuyama T.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪府、大阪市）
  • Year and Date: 2015-04-24