| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We investigated whether iron is involved in AAA formation using human AAA tissues and murine AAA models. Iron was accumulated in human and murine AAA tissues compared with non-AAA tissues, and iron accumulated area was closed to oxidative stress marker positive area and macrophage infiltrated area. We next investigated the effects of dietary iron restriction on AAA formation in mice. Iron restriction reduced the incidence of AAA formation with attenuation of oxidative stress and inflammation in AAA mice. Aortic expression of TfR1, intracellular iron transport protein, was increased in human and murine AAA tissues. Iron is involved in AAA formation, and aortic iron metabolism may be a new therapeutic target for AAA formation.
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