Development of new treatment strategy in peripheral artery disease using apoA-I mimetic peptide

• Project/Area Number: 26860591
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Fukuoka University
• Principal Investigator: Imaizumi Satoshi 福岡大学, 医学部, 准教授 (60609478)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: ApoA-I模倣ペプチド / 下肢虚血 / 血管新生 / NO / HDL / FAMP / アポA-I模倣ペプチド / ＮＯ

Outline of Final Research Achievements

It is unclear whether an apoA-I mimetic peptide can promote neovascularization in vivo. Here, we investigated the effect of FAMP on endothelial nitric oxide synthase (eNOS) activation and angiogenesis in a murine hindlimb ischemia model. As a result, FAMP promoted recovery from hindlimb ischemia through a nitric oxide (NO)-related pathway by activation of a PI3K / Akt pathway. FAMP may become a new therapeutic agent for the future clinical treatment of peripheral artery disease (PAD).

Research Products

• [Journal Article] Newly developed apolipoprotein A-I mimetic peptide promotes macrophage reverse cholesterol transport in vivo. (2015)
  • Author(s): Shimizu T, Tanigawa H, Miura S, Kuwano T, Takata K, Suematsu Y, Imaizumi S, Yahiro E, Zhang B, Uehara Y, Saku K.
  • Journal Title: Int J Cardiol. Volume: 192 Pages: 82-88
  • DOI: 10.1016/j.ijcard.2016.01.012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Inhibition of lipopolysaccharide induced gene expression by HDL from healthy subjects and patients with acute myocardial infarction. (2016)
  • Author(s): Imaizumi S, Takata K, Yahiro E, Kawachi E, Iwata A, Uehara Y, Zhang B, Miura S, Saku K.
  • Organizer: ESC congress 2016
  • Place of Presentation: Rome
  • Year and Date: 2016-08-27
  • Int'l Joint Research
• [Presentation] FAMP (Fukuoka University Apo A-1 Mimetic peptide) ameliorates impaired HDL function with activation of NO related pathway (2015)
  • Author(s): 高田 耕平
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-26
• [Presentation] ApoA-I mimetic peptide FAMP induces neovascularization through activation of endothelial cell nitric oxide related pathway (2014)
  • Author(s): 高田 耕平
  • Organizer: ESC（欧州心臓病学会）
  • Place of Presentation: バルセロナ（スペイン）
  • Year and Date: 2014-09-02