| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We developed the peptide which can be used for PET imaging to visualize aortic plaque. In order to clarify the mechanism of action and the target molecule of FAMP, we successfully synthesized FITC-FAMP which possesses same functionality with FAMP. We supposed FAMP which adheres to the monocyte is transported to the atherosclerotic lesions, and integrated into the site of inflammation or plaques. However, neutrophil was positive with FITC-FAMP in the FACS system. It was suggested that FAMP adheres to neutrophils in blood and accumulates into the sites of inflammation or arteriosclerotic lesions.
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