The analysis of mechanisms of induction of Th2 type immune response by MV infection

• Project/Area Number: 26860593
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Hokkaido University
• Principal Investigator: Ariki Hiromi 北海道大学, 医学(系)研究科(研究院), 助教 (40515061)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 麻疹ウイルス / IL-4 / IL-13 / I型IFN / 樹状細胞

Outline of Final Research Achievements

Measles virus (MV) is a highly pathogenic non-segmented negative-strand RNA virus that causes respiratory distress and immune suppression upon infection of its human host. Human CD150 is one of MV entry receptors. Human CD150Tg/Ifnar KO mice, which are generated by crossing CD150Tg mice with Ifnar KO mice, are susceptible to MV infection and serve as a useful mouse model. Using these mice, I investigated host immune responses against MV infection in vivo.

Research Products

• [Journal Article] MAVS/TICAM-1-independent interferon-inducing pathway contributes to regulation of hepatitis B virus replication in the mouse hydrodynamic injection model (2015)
  • Author(s): Leong CR, Oshiumi H, Okamoto M, Azuma M, Takaki H, Matsumoto M, Chayama K, Seya T
  • Journal Title: J Innate Immunology Volume: 7 Issue: 1 Pages: 47-58
  • DOI: 10.1159/000365113
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response. (2015)
  • Author(s): Takashima K, Oshiumi H, Takaki H, Matsumoto M, Seya T.
  • Journal Title: Cell Rep. Volume: 11 Pages: 192-200
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] PolyI:C-induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo (2015)
  • Author(s): Ryo Takemura, Hiromi Takaki, Seiji Okada, Hiroaki Shime, Takashi Akazawa, Hiroyuki Oshiumi, Misako Matsumoto, Takanori Teshima, and Tsukasa Seya
  • Journal Title: Cancer Immunology Research Volume: 3 Issue: 8 Pages: 902-914
  • DOI: 10.1158/2326-6066.cir-14-0219
  • NAID: 120005820710
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Evolution of the DEAD box helicase family in chicken: chickens have no DHX9 ortholog (2015)
  • Author(s): Haruko Sato, Hiroyuki Oshiumi, Hiromi Takaki, Hirokazu Hikono, and Tsukasa Seya
  • Journal Title: Microbiology and Immunology Volume: 59 Issue: 10 Pages: 633-640
  • DOI: 10.1111/1348-0421.12322
  • NAID: 120005906889
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] MAVS-dependent IRF3/7 bypass of interferon beta-induction restricts the response to measles infection in CD150Ta mouse bone marrow-derived dendritic cells. (2014)
  • Author(s): Hiromi Takaki, et al.
  • Journal Title: Molecular Immunology Volume: 57 Issue: 2 Pages: 100-110
  • DOI: 10.1016/j.molimm.2013.08.007
  • Peer Reviewed
• [Journal Article] Dendritic cell subsets involved in type I IFN induction in mouse measles virus infection models (2014)
  • Author(s): Hiromi Takaki, Hiroyuki Oshiumi, Misako Matsumoto, Tsukasa Seya
  • Journal Title: The international Journal of Biochemistry & Cell Biology Volume: 53 Pages: 329-333
  • DOI: 10.1016/j.biocel.2014.05.001
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo. (2015)
  • Author(s): Hiromi Takaki, Hiroaki Shime, Misako Matsumoto, Tsukasa Seya
  • Organizer: 日本免疫学会
  • Place of Presentation: 札幌コンベンションセンター（北海道・札幌）
  • Year and Date: 2015-11-18