Three dimensional CT analysis of airways in COPD, asthma

• Project/Area Number: 26860594
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Hokkaido University
• Principal Investigator: Shimizu Kaoruko 北海道大学, 大学病院, 特任助教 (40399853)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 慢性閉塞性肺疾患 / CT / 気管支拡張薬 / CT3次元気道解析 / 気道 / 気腫 / 3次元気道解析 / COPD / 気道病変

Outline of Final Research Achievements

GOLD guideline provides a treatment algorism for management of chronic obstructive pulmonary disease (COPD), of which the mainstay is bronchodilators of long acting β2 agonists (LABA) and long acting anti-cholinergics (LAMA). Monotherapy is used for mild COPD patients while a combination therapy is taken for more severe COPD patients. The more marked bronchodilation with tiotropium(LAMA) was seen in the more distal parts in the 3rd to 6th generation of airways, which was not found in the SFC(LABA/inhaled corticosteroids) study.(European J of Radiol 2015) We have conducted another study to confirm the site specific pattern of LABA/LAMA combination therapy. Bronchodilation pattern was not significantly different between LABA and LABA/LAMA combination therapy.

Research Products

• [Journal Article] Regional bronchodilator response assessed by computed tomographyin chronic obstructive pulmonary disease (2015)
  • Author(s): Shimizu K, Makita H, Hasegawa M, Kimura H, Fuke S, Nagai K, Yoshida T, Suzuki M, Konno S, Ito Y, ,Nishimura M
  • Journal Title: European Journal of Radiology Volume: 10 Issue: 6 Pages: 1196-1201
  • DOI: 10.1016/j.ejrad.2015.02.022
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Regional bronchodilator response assessed by computed tomography in chronic obstructive pulmonary disease (2016)
  • Author(s): Kaoruko Shimizu
  • Organizer: 第65回日本アレルギー学会学術大会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2016-06-17
• [Presentation] Regional bronchodilator response assessed by computed tomography in chronic obstructive pulmonary disease (2016)
  • Author(s): Kaoruko Shimizu
  • Organizer: 第1回 アジア・オセアニア呼吸機能イメージングワークショップ／ 第8回 呼吸機能イメージング研究会学術集会
  • Place of Presentation: 淡路夢舞台国際会議場（兵庫県淡路島）
  • Year and Date: 2016-01-29