Activated protein C for the therapy of allergic diseases
Project/Area Number |
26860605
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Respiratory organ internal medicine
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Research Institution | Mie University |
Principal Investigator |
Takagi Takehiro 三重大学, 医学(系)研究科(研究院), リサーチアソシエイト (70585174)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | アレルギー / 凝固制御因子 / 肥満細胞 / 好酸球 / 喘息 / 活性化プロテインC / トロンボモジュリン / 気道過敏性 / 気道リモデリング / 樹状細胞 / 凝固系 / サイトカイン / T細胞 |
Outline of Final Research Achievements |
Activated protein C (APC) is a natural anticoagulant that can also play an important role in the modulation of inflammatory, immune and allergic responses. APC results from the activation of protein C by the thrombin and thrombomodulin (TM) complex. TM can also exhibit anti-inflammatory and anti-allergic properties. The present study was undertaken to assess whether recombinant human (rh) TM can inhibit the allergic responses of mast cells and eosinophils, and whether APC can block the maturation of dendritic cells. This study showed that rhTM suppresses airway hyperresponsivenes, infiltration of eosinophils and degranulation/activation of mast cells in an allergic bronchial asthma mouse model. In addition, this study demonstrated that APC can inhibit the activation and maturation of mouse bone marrow-derived dendritic cells. Overall, these results suggest the potential usefulness of both rhTM and APC for treating allergic diseases.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] irculating fibrocytes correlate with the asthma control test score.2016
Author(s)
Kobayashi H, Naito M, Masuya M, Maruyama M, Urata K, Takahashi Y, Tomaru A,Fujiwara K, Ohnishi M, Takagi T, Kobayashi T,D'Alessandro-Gabazza C, Urawa M,Gabazza EC, Taguchi O, Takei Y.
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Journal Title
Allergol Immunopathol (Madr).
Volume: 44
Issue: 3
Pages: 152-154
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Thrombomodulin Modulates Dendritic Cells via Both Antagonism of High Mobility Group Protein B1 and an Independent Mechanism2014
Author(s)
Toda M, D'Alessandro-Gabazza CN, Takagi T, Chelakkot-Govindalayathila AL, Taguchi O, Roeen Z, Munesue S, Yamamoto Y, Yamamoto H, Gabazza EC, Morser J.
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Journal Title
Allergology International
Volume: 63
Issue: 1
Pages: 57-66
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access
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[Presentation] Matrix metalloproteinase-2 is protective in bleomycin-induced pulmonary fibrosis.2015
Author(s)
1.Tomaru A, Gabazza E, Kobayashi T, Kobayashi H, Taguchi O, Takagi T, Oonishi M, Fujiwara K, D'Alessandro Gabazza C, Takahashi Y, Urata K.
Organizer
International Conference of the European Respiratory Society, Netherlands
Place of Presentation
オランダ アムステルダム
Year and Date
2015-09-26
Related Report
Int'l Joint Research
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[Presentation] Lung overexpression of matrix metalloproteinase-2 protects against bronchial asthma.2015
Author(s)
2.Fujiwara K, Urata K, Tomaru A, Takahashi Y, Onishi M, Takagi T, Kobayashi H, D'Alessandro Gabazza CN, Gabazza EC, Taguchi O, Kobayashi T.
Organizer
International Conference of the European Respiratory Society, Netherlands
Place of Presentation
オランダ アムステルダム
Year and Date
2015-09-26
Related Report
Int'l Joint Research
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[Presentation] The immunomodulatory activity of protein S protects against allergic airway inflammation.2015
Author(s)
3.Takahashi Y, Urata K, Tomaru A, Fujiwara K, Onishi M, Takagi T, Kobayashi H, D'Alessandro-Gabazza C, Gabazza E, Osamu Taguchi O, Kobayashi T.
Organizer
International Conference of the European Respiratory Society, Netherlands
Place of Presentation
オランダ アムステルダム
Year and Date
2015-09-26
Related Report
Int'l Joint Research
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