The mechanisms of EGF signaling suppression by pulmonary surfactant protein.
Project/Area Number |
26860611
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Respiratory organ internal medicine
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Research Institution | Sapporo Medical University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
MOTOKO TAKAHASHI 札幌医科大学, 医学部, 准教授 (00303941)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 肺サーファクタント蛋白質 / EGFR / 肺がん / 肺サーファクタント / SP-A / SP-D |
Outline of Final Research Achievements |
Our previous study has indicated that SP-D suppresses EGF signaling by interfering with the ligand-binding to EGFR. SP-D directly binds to the N-glycans of EGFR by lectin activity. In this study, we indicated that SP-A also downregulated EGF signaling by inhibiting ligand-binding to EGFR. In addition, we found that SP-A directly bound to EGFR, but not via N-glycans. Elucidating the antitumor effects of SP-A and SP-D may provide important clues for establishing new therapeutic strategies for lung cancer.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] SP-A及びSP-A由来ペプチドはヒトβ-ディフェンシン3による肥満細胞の遊走を抑制する2016
Author(s)
(1)有木茂, 上原康昭, 村田雅樹, 高宮里奈, 長谷川喜弘, 齋藤充史, 千葉弘文, 黒沼幸治, 高橋素子, 高橋弘毅, 黒木由夫
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Journal Title
分子呼吸器病
Volume: 20
Pages: 123-123
Related Report
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[Journal Article] Surfactant protein D suppresses lung cancer progression by downregulation of epidermal growth factor signaling2015
Author(s)
Hasegawa Y, Takahashi M, Ariki S, Asakawa D, Tajiri M, Wada Y, Yamaguchi Y, Nishitani C, Takamiya R, Saito A, Uehara Y, Hashimoto J, Kurimura Y, Takahashi H, Kuroki Y
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Journal Title
Oncogene
Volume: 34
Issue: 7
Pages: 838-845
DOI
Related Report
Peer Reviewed
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[Presentation] 肺サーファクタント蛋白質AとDによるEGFシグナルの抑制作用2014
Author(s)
長谷川喜弘, 高橋素子, 有木茂, 高宮里奈, 上原康昭, 橋本次郎, 浅川大樹, 田尻道子, 和田芳直, 高橋弘毅, 黒木由夫
Organizer
第87回日本生化学会
Place of Presentation
京都
Year and Date
2014-10-15 – 2014-10-18
Related Report
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