Role of FBXO17 in EGFR mutation positive NSCLC
Project/Area Number |
26860614
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Respiratory organ internal medicine
|
Research Institution | Keio University |
Principal Investigator |
HAMAMOTO JUNKO 慶應義塾大学, 医学部, 特任助教 (40570239)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | EGFR / FBXO17 / 肺癌 |
Outline of Final Research Achievements |
We found that knockdown of FBXO17 induced cell growth arrest in 6 lung cancer cell lines out of tested 8 cell lines. Not all but some lung cancer cell lines showed up-regulation of phosphorylated ERK by FBXO17 overexpression. Moreover, G1/S cell cycle checkpoint was disrupted by FBXO17 overexpression in all tested lung cancer cell lines. We could not identify the binding protein of FBXO17, but we've suggested that FBXO17 is an important gene implicating in cell growth, cell cycle and EGFR pathway.
|
Report
(3 results)
Research Products
(1 results)
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[Presentation] FBOXO17(F-box protein 17)が非小細胞肺癌細胞株の増殖に及ぼす影響の検討。2014
Author(s)
宮脇正芳, 副島研造, 西野誠, 大芦彩野, 黒田葵, 谷哲夫, 荒井大輔, 石岡宏太, 扇野圭子, 佐藤崇, 浜本純子, 安田浩之, 猶木克彦, 別役智子
Organizer
第54回日本呼吸器学会学術総会
Place of Presentation
大阪国際会議場、リーガロイヤルホテル(大阪府大阪市北区)
Year and Date
2014-04-25 – 2014-04-27
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